Registration Dossier
Registration Dossier
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EC number: 242-615-9 | CAS number: 18835-33-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A measured BCF is not available for hexacos-1-ene. A calculated log BCF of <2.64 has been read across from icos-1-ene.
Key value for chemical safety assessment
Additional information
A measured BCF is not available for hexacos-1 -ene. As the calculated log Kow of hexacos-1-ene is >3 the bioaccumulation endpoint cannot be waived. However, ECHA's Guidance on Information Requirements and Chemical Safety Assessment R7c Endpoint Specific Guidance (2008) indicates that before commissioning a new vertebrate test, alternative sources of data on the bioaccumulation potential of a chemical should be used.
Non-polar substances have been shown to have a linear relationship between log Kow and BCF in the log Kow range 1 - 6. However, at log Kow >6 a decreasing relationship is observed. Several QSARs have been developed that calculate the BCFs of non-polar, hydrophobic compounds on the basis of their log Kow (e.g. Connell and Hawker, 1988; USEPA, 2008). Hexacos-1-ene falls outside the applicability domain of both QSARs, therefore data have been read across from category members with lower carbon numbers. Icos-1-ene is the largest C number alpha olefin whose log Kow falls within the applicability domain of the QSARs. Based on read across from this substance the log BCF of hexacos-1-ene is expected to be <2.64.
The log Kow of hexacos-1-ene has been calculated in KOWWIN (log Kow 12.97) and SPARC (log Kow 15.15). ECHA's Guidance on Information Requirements and Chemical Safety Assessment - Part C: PBT Assessment (2008) states that the aquatic BCF of a substance is probably lower than 2000 L/kg if the calculated log Kow is higher than 10. As none of the Kow models have experimental data in this Kow range the reliability of modelled Kow values >10 is not known. However, as both models indicate a log Kow >10 we can conclude that hexacos-1-ene is unlikely to bioaccumulate.
Taken together, this information indicates that hexacos-1 -ene is not expected to bioaccumulate or pose a risk of secondary poisoning.
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