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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Description of key information

A measured BCF is not available for hexacos-1-ene. A calculated log BCF of <2.64 has been read across from icos-1-ene.

Key value for chemical safety assessment

Additional information

A measured BCF is not available for hexacos-1 -ene. As the calculated log Kow of hexacos-1-ene is >3 the bioaccumulation endpoint cannot be waived. However, ECHA's Guidance on Information Requirements and Chemical Safety Assessment R7c Endpoint Specific Guidance (2008) indicates that before commissioning a new vertebrate test, alternative sources of data on the bioaccumulation potential of a chemical should be used.

Non-polar substances have been shown to have a linear relationship between log Kow and BCF in the log Kow range 1 - 6. However, at log Kow >6 a decreasing relationship is observed. Several QSARs have been developed that calculate the BCFs of non-polar, hydrophobic compounds on the basis of their log Kow (e.g. Connell and Hawker, 1988; USEPA, 2008). Hexacos-1-ene falls outside the applicability domain of both QSARs, therefore data have been read across from category members with lower carbon numbers. Icos-1-ene is the largest C number alpha olefin whose log Kow falls within the applicability domain of the QSARs. Based on read across from this substance the log BCF of hexacos-1-ene is expected to be <2.64.

The log Kow of hexacos-1-ene has been calculated in KOWWIN (log Kow 12.97) and SPARC (log Kow 15.15). ECHA's Guidance on Information Requirements and Chemical Safety Assessment - Part C: PBT Assessment (2008) states that the aquatic BCF of a substance is probably lower than 2000 L/kg if the calculated log Kow is higher than 10. As none of the Kow models have experimental data in this Kow range the reliability of modelled Kow values >10 is not known. However, as both models indicate a log Kow >10 we can conclude that hexacos-1-ene is unlikely to bioaccumulate.

Taken together, this information indicates that hexacos-1 -ene is not expected to bioaccumulate or pose a risk of secondary poisoning.