Registration Dossier
Registration Dossier
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EC number: 236-138-5 | CAS number: 13185-09-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: In silico prediction.
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- March 1 - May 14, 2010
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Skin irritation module estimates the potential of a compound to cause skin irritation in a standard rabbit Draize test.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology. - GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
- EC Number:
- 236-138-5
- EC Name:
- 1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
- Cas Number:
- 13185-09-6
- Molecular formula:
- C14H12N2O.Na
- IUPAC Name:
- sodium 1-benzyl-3-oxo-2,3-dihydro-1H-indazol-2-ide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Number of animals:
- No animals used.
Results and discussion
In vivo
Results
- Remarks on result:
- other: No alert came be observed for skin irritation test by Tox Boxes 2.9 (software for the prediction)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- No alert came be observed for skin irritation test by Tox Boxes 2.9 (software for the prediction)
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