Registration Dossier
Registration Dossier
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EC number: 236-138-5 | CAS number: 13185-09-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- March 1 - May 14, 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to the prediction of toxicity delivered by the software Tox Boxes 2.9, Acute Toxicity overview indicates value with moderate and borderline reliability index.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology. - GLP compliance:
- no
Test material
- Reference substance name:
- 1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
- EC Number:
- 236-138-5
- EC Name:
- 1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt
- Cas Number:
- 13185-09-6
- Molecular formula:
- C14H12N2O.Na
- IUPAC Name:
- sodium 1-benzyl-3-oxo-2,3-dihydro-1H-indazol-2-ide
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- other: intraperitoneal, intravenous, subcutaneous
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 340 mg/kg bw
- Remarks on result:
- other: The intraperitoneal toxicity overview indicates values with moderate reliability index by Tox Boxes 2.9 (software for the prediction).
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 69 mg/kg bw
- Remarks on result:
- other: The intravenous toxicity overview indicates values with borderline reliability index by Tox Boxes 2.9 (software for the prediction).
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 430 mg/kg bw
- Remarks on result:
- other: The subcutaneous toxicity overview indicates values with moderate reliability index by Tox Boxes 2.9 (software for the prediction).
Applicant's summary and conclusion
- Conclusions:
- The acute toxicity overview for intraperitoneal, intravenous and subcutaneous routes in mouse indicates values with moderate and borderline reliability index by Tox Boxes 2.9 (software for the prediction).
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