Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
The assessment of the toxicokinetics of (2,4,6-trioxotriazine-1,3,5(2H,4H,6H)-triyl)tris(hexamethylene) isocyanate, is based on read-across of physico-chemical properties and toxicological data of HDI oligomers, isocyanurate type. Experimental toxicokinetic studies were not performed.

Data source

Reference Type:
other: Toxicokinetic Assessment
Report date:

Materials and methods

Principles of method if other than guideline:
assessment on toxicokinetics

Test material

Constituent 1
Reference substance name:
HDI oligomers, isocyanurate
HDI oligomers, isocyanurate

Results and discussion

Any other information on results incl. tables

For (2,4,6-trioxotriazine-1,3,5(2H,4H,6H)-triyl)tris(hexamethylene) isocyanate (EC 223-242-0, CAS 3779-63-3, mono constituent substance), in the following referred to as "HDI Trimer pure", a read across from the close structural analogue HDI oligomers, isocyanurate type (EC 931-274-8, CAS 28182-81-2, UVCB) is applied. A justification for the read-across with special focus on inhalation toxicity was elaborated and is attached to this endpoint summary. Based on this justification all available toxicological data for HDI oligomers, isocyanurate type can be used for the toxicological evaluation of HDI Trimer pure and the conclusions drawn with respect to toxicokinetics of HDI oligomers, isocyanurate type are also valid for HDI Trimer pure. This approach is in accordance with Annex XI, section 1.5 of the REACH Regulation (EC) No 1907/2006.

(All available data for HDI oligomers, isocyanurate type, EC 931-274-8, at


Applicant's summary and conclusion