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Registration Dossier
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EC number: 203-004-2 | CAS number: 102-08-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental start: 06/06/11 - Experimental end: 10/06/11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 24.37 mg/L
- Temp.:
- 20 °C
- pH:
- 5.84
- Remarks on result:
- other: Mean values
- Water solubility:
- 23.95 mg/L
- Temp.:
- 20 °C
- pH:
- 6.11
- Water solubility:
- 23.52 mg/L
- Temp.:
- 20 °C
- pH:
- 5.75
- Water solubility:
- 25.65 mg/L
- Temp.:
- 20 °C
- pH:
- 5.67
- Details on results:
- See "Any other information on results incl. tables".
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the test item 1,3 - Diphenyl -2- Thiourea was assessed according to the OECD guideline 105. It was estimated at 24.37 mg/l. During the analysis,the temperature was 20 +/- 0.5°C and the mean value of pH was 5.84. - Executive summary:
The water solubility of the test item 1,3 - Diphenyl -2- Thiourea was assessed according to the OECD guideline 105.
During the analysis,the temperature was 20 +/- 0.5°C and the mean value of pH was 5.84.
The values of the replicates are reported below:
Test
Results
Water Solubility
OECD105 – Flask Method
pH
Water Solubility at 20°C, mg/L
TestT24 h
TestT48 h
TestT72 h
6.11
5.75
5.67
23.95
23.52
25.65
Mean value
5.84
24.37
Based on these values, 1,3 -diethyl-2 -thiourea can be considered as slightly soluble in water.
Reference
Water solubility results of each replicate are presented in the following table:
Sample
|
pH |
Test item concentration measured in each flask, mg/L |
T24 h
|
6.38 – 5.85 |
23.8 – 24.1 |
T48 h
|
5.73 – 5.77 |
23.45 – 23.6 |
T72 h
|
5.75 – 5.59 |
26.4 – 24.75 |
Average concentration
|
- |
24.37 |
As required by the Guideline, the concentrations measured at each time point do not differ by more than 15 %.
Description of key information
The water solubility was assessed according to the OECD guideline 105.
Key value for chemical safety assessment
- Water solubility:
- 24.37 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item 1,3 - Diphenyl -2- Thiourea was assessed according to the OECD guideline 105.
During the analysis,the temperature was 20 +/- 0.5°C and the mean value of pH was 5.84.
The values of the replicates are reported below:
Test |
Results |
|
Water Solubility OECD105 – Flask Method |
pH |
Water Solubility at 20°C, mg/L
|
TestT24 h TestT48 h TestT72 h |
6.11 5.75 5.67 |
23.95 23.52 25.65 |
Mean value |
5.84 |
24.37 |
Based on these values,1,3 -diethyl-2 -thiourea can be considered as slightly soluble in water.
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