Registration Dossier
Registration Dossier
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EC number: 203-874-3 | CAS number: 111-48-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- 2,2'-thiodi-ethanol
- Author:
- RTECS, Registry of toxic effects of chemical substances
- Year:
- 2 008
- Reference Type:
- publication
- Title:
- Toxicity assessment of thiodiglycol
- Author:
- Reddy G, Major MA, Leach GJ
- Year:
- 2 005
- Bibliographic source:
- Int J Toxicol 24:435–442
Materials and methods
- Principles of method if other than guideline:
- LD50 in rabbits after dermal application
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Thiodiglycol
- EC Number:
- 203-874-3
- EC Name:
- Thiodiglycol
- Cas Number:
- 111-48-8
- Molecular formula:
- C4H10O2S
- IUPAC Name:
- 2-[(2-hydroxyethyl)sulfanyl]ethan-1-ol
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 23 600 mg/kg bw
Any other information on results incl. tables
original value: LD50 = 20 ml/kg
no further data available
Applicant's summary and conclusion
- Conclusions:
- LD50 in rabbits after dermal application is 23600 mg/kg bw.
- Executive summary:
Secondary literature.
LD50 in rabbits after dermal application is 23600 mg/kg bw.
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