2-(methylamino)ethanol, compound with sulphur dioxide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable non-GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Principles of method if other than guideline:

BASF test (inhalation hazard test) according to Smyth et al. (1962). The test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of the test item at 20 °C.

Reference:
Smyth HF et al. (1962). Am. Ind. Hyg. Ass. J. 23: 95-107.

GLP compliance:

no

Test type:

other: inhalation hazard test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-(methylamino)ethanol, compound with sulphur dioxide

EC Number:

244-169-0

EC Name:

2-(methylamino)ethanol, compound with sulphur dioxide

Cas Number:

21049-70-7

Molecular formula:

C3H9NO.xO2S

IUPAC Name:

(oxo-λ⁴-sulfanylidene)oxidane; 2-(methylamino)ethan-1-ol

Details on test material:

- Name of test material: Kauramin-Härter CE 5162 flüssig; N-Methyläthanolammonium(-hydrogen) sulfit in Wasser (German)
- Physical state: liquid
- Composition of test material, percentage of components: N-Methylethanolamine: 49.4 %, Sulfur dioxide: 29.5 %, Water: 21.1 %

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: purchased from a breeder
- Age at study initiation: young adult

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 200 L/hour
- System of generating a saturated vapour atmosphere: air was bubbled through a substance column of about 5 cm above a fritted glass disk in a glass cylinder.
- Temperature in air chamber: 20 °C

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

Saturated atmosphere, enriched with the volatile fraction of the test substance

No. of animals per sex per dose:

6 rats

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: group-wise documentation of clinical signs was performed; body weight of groups was determined before the start of the study and at the end of the observation period in surviving animals.
- Necropsy of survivors performed: yes

Statistics:

No statistical analysis was performed.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

other: saturated atmosphere

Based on:

test mat.

Exp. duration:

7 h

Remarks on result:

other: There were no effects.

Mortality:

There were no deaths.

Clinical signs:

other: There were no clinical signs.

Body weight:

No data

Gross pathology:

There were no test substance-related macroscopic findings.