Registration Dossier
Registration Dossier
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EC number: 217-101-2 | CAS number: 1739-84-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- prior to the adoption of OECD403 in 1981
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dimethylimidazole
- EC Number:
- 217-101-2
- EC Name:
- 1,2-dimethylimidazole
- Cas Number:
- 1739-84-0
- Molecular formula:
- C5H8N2
- IUPAC Name:
- 1,2-dimethyl-1H-imidazole
- Details on test material:
- Name of testmaterial (as cited in study report): 1,2-Dimethylimidazol
Substance number: 77/683
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF-Zucht, Firma MUS RATTUS, Brunnthal
- Weight at study initiation: 185 +/- 15 g
- Diet: Herilan MRH (Firma H. Eggersmann, Rinteln/Weser), ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Aerosol generation: generated using a continuous infusion pump to lead the water/substance mixture (50%) through a two-fluid nozzle with compressed air
-Tubes in which the snout extends into an inhalation chamber for exposure - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 3.01 mg/l (analytical), 19.59 mg/l (nominal)
2.39 mg/l (analytical), 15.33 mg/l (nominal) - No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight - Statistics:
- The statistical analysis of the experiment was based on the binomial test by the computational center at BASF.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: conversion of the 4-h LC50 according to the Haber-rule
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: conversion of the 4-h LC50 according to the Haber-rule
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: conversion of the 4-h LC50 according to the Haber-rule
- Mortality:
- No mortality occured
- Clinical signs:
- other: Watery, reddish eyes and nasal secretions. Shock manner or rapid breathing. Long-legged, tumbling movement. Scruffy look. Matted fur. Alopecia. 2 out of 20 male animals showed nose burns. On the day of necropsy symptoms were still recorded.
- Body weight:
- Slight differences in body weight gain were observed in the test groups compared to the control group.
- Gross pathology:
- No treatment related findings.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
