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Physical & Chemical properties

Partition coefficient

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Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
Pow
Partition coefficient:
0.37
Temp.:
22 °C
pH:
5.8
Type:
log Pow
Partition coefficient:
-0.43
Temp.:
22 °C
pH:
5.8
Conclusions:
The partition coefficient of the test substanc at 22°C was determined to be:
POW: 0.37
log POW: - 0.43
Executive summary:

The partition coefficient of the test item was determined according to the European Commission Council Regulation (EC) No. 440/2008, Annex, Part A, A.8 and OECD Test Guideline 107.

The tests were performed using 3 different phase ratios of 1-octanol / water: Test A and B: Phase ratio = 2 : 1, Test C and D: Phase ratio = 1 : 1, Test E and F: Phase ratio = 1 : 2.

119.60 mg (initial weight) of the test item were dissolved in 100 mL of distilled water (saturated with 1-octanol). The required volumes of the two solvents and the sample stock solution were transferred into the vials which were tightly crimped afterwards.

Each of the six flasks was shaken (approximately 3 h) at room temperature (22 °C). To obtain the separation of the phase systems, the vials were left standing at test temperature until both phases were clear (over night). From each phase samples were drawn by Pasteur pipettes (1-octanol phase) and disposable needles with single-use syringes (aqueous phase) respectively.

The partition coefficient of the test substanc at 22°C was determined to be: POW: 0.37, log POW: - 0.43

Description of key information

The partition coefficient of the test item was determined according to the European Commission Council Regulation (EC) No. 440/2008, Annex, Part A, A.8 and OECD Test Guideline 107.

The tests were performed using 3 different phase ratios of 1-octanol / water: Test A and B: Phase ratio = 2 : 1, Test C and D: Phase ratio = 1 : 1, Test E and F: Phase ratio = 1 : 2.

119.60 mg (initial weight) of the test item were dissolved in 100 mL of distilled water (saturated with 1-octanol). The required volumes of the two solvents and the sample stock solution were transferred into the vials which were tightly crimped afterwards. Each of the six flasks was shaken (approximately 3 h) at room temperature (22 °C). To obtain the separation of the phase systems, the vials were left standing at test temperature until both phases were clear (over night).

The partition coefficient of the test substanc at 22°C was determined to be: POW: 0.37, log POW: - 0.43

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.43
at the temperature of:
22 °C

Additional information