Registration Dossier
Registration Dossier
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EC number: 238-953-1 | CAS number: 14882-18-9
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16/04/2018 - 04/09/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- bismuth subsalicylate
- IUPAC Name:
- bismuth subsalicylate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Product name: Bismuth Subsalicylate
Constituent 1
- Specific details on test material used for the study:
- Batch/Lot Number: 2018000421
Results and discussion
- Dissociating properties:
- not determined
- Remarks:
- Dissociation constant of the test item could not be determined under the conditions of this study.
Applicant's summary and conclusion
- Conclusions:
- Dissociation constant cannot be calculated because of low solubility. As the substance does not dissolve, it cannot dissociate in water.
- Executive summary:
The dissociation of a chemical in water is of importance in assessing its impact upon the environment. It governs the form of the substance which in turn determines its behaviour and transport. It may affect the adsorption of the chemical on soils and sediments and adsorption into biological cells.
According to the OECD No. 112 guideline, three methods are available for dissociation constant determination. As the test item had no light absorption properties, the spectrophotometric method could not be used. As approximately 0.1 M solution of the test item was not achievable, the conductometry method could not be used either. Therefore, the titration method was applied.
Dissociation constant of the test item could not be determined under the conditions of this study. It was considered that the low solubility of the test item prevented the titration method from being feasible (the titration method is not suitable for low solubility substances).
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