1,3-Benzenediamine, 2,4,6-tris(1-methylethyl)-

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

2008

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,4,6-tris(propan-2-yl)benzene-1,3-diamine

Cas Number:

6318-09-8

Molecular formula:

C12H26N2

IUPAC Name:

2,4,6-tris(propan-2-yl)benzene-1,3-diamine

Details on test material:

yellowish powder

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not required

Duration of treatment / exposure:

1 hour

Observation period (in vivo):

1 h, 24 h, 48 h and 72 h

Number of animals or in vitro replicates:

3

Results and discussion

In vivo

Results

Irritation parameter:

maximum mean total score (MMTS)

Basis:

mean

Time point:

other: 72 h

Score:

2

Max. score:

6

Reversibility:

fully reversible

Any other information on results incl. tables

animal		1 h	24 h	48 h	72 h
1	cornea	0	0	0	0
	iris	0	0	0	0
	conjunctivae	1	1	0	0
	overall score	2	2	0	0
2	cornea	0	0	0	0
	iris	0	0	0	0
	conjunctivae	2	1	0	0
	overall score	4	2	0	0
3	cornea	0	0	0	0
	iris	0	0	0	0
	conjunctivae	3	1	0	0
	overall score	6	2	0	0

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS