Registration Dossier
Registration Dossier
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EC number: 801-656-8 | CAS number: 1416808-92-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde
- EC Number:
- 801-656-8
- Cas Number:
- 1416808-92-8
- Molecular formula:
- C8H9ClO2
- IUPAC Name:
- (3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of test animal above serves as control
- Duration of treatment / exposure:
- see observation
- Observation period (in vivo):
- Mortality/viability: twice daily
Toxicity: at least once daily
Body weight: day of treatment (prior to instillation) and at termination
Irritation: aproximately 1, 24, 48 and 72 hours after instillation of the test substance - Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal: only 1 animal used in this test
- Time point:
- other: mean 24-72 hours
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- iris score
- Basis:
- animal: only 1 animal used in this test
- Time point:
- other: mean 24-72 hours
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- other: redness
- Basis:
- animal: only 1 animal used in this test
- Time point:
- other: mean 24-72 hours
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal: only 1 animal used in this test
- Time point:
- other: mean 24-72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Other effects:
- Yellow staining of the fur on the head and paws, caused by the test substance, was noted during the observation period.
No symptoms of systemic toxicity were observed in the animal during the test period and no mortality occurred.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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