Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

The potential for bioaccumulation in aquatic organisms (most likely in fish) was not determined experimentally for Choline hydrogen carbonate. It was not possible to determine the logPow experimentally and based on the substance composition, a bioaccumulation study can be waived in accordance to REACH, Annex IX, Section 9.3.2, column 2.

The Bioconcentration factor (BCF) is an important parameter for the chemical safety assessment (CSA) and is therefore mostly determined with scientifically accepted QSAR predictions. In the case for Choline hydrogen carbonate, however, such a prediction is not possible. The substance is lying out of the domain in the EPIWIN software BCFBAF v3.01. Therefore, the prediction result for the reliable read-across substance Choline chloride (CAS 67-48-1) is taken into account (Chemservice S.A., 2013). Using the regression-based estimate (traditional method) a BCF of 3.16 L/kg wet-wt was predicted. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 0.893 L/kg wet-wt is the result. These results confirm that bioaccumulation in aquatic organisms is unlikely for the read-across substance and the same can be considered for the target one. For details and justification of the read-across procedure, please refer to the separate read-across statement (Chemservice S.A., 2013).

Also terrestrial bioaccumulation of Choline hydrogen carbonate is not expected. However, no information is available and this endpoint is no mandatory requirement under REACH.