Registration Dossier
Registration Dossier
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EC number: 700-402-2 | CAS number: 860035-10-5
Guidance on Safe Use
Guidance on Safe Use
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Administrative data
First-aid measures
Ingestion Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the
exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the
exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.
Inhalation Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing
is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed
subject should be kept warm and at rest. Obtain medical attention in cases of known or possible
over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness
or other adverse effects, which may be delayed.
Skin contact Using appropriate personal protective equipment, remove contaminated clothing and flush
exposed area with large amounts of soap and water. Obtain medical attention if skin reaction
occurs, which may be immediate or delayed.
Eye contact Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain
medical attention.
exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the
exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.
Inhalation Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing
is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed
subject should be kept warm and at rest. Obtain medical attention in cases of known or possible
over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness
or other adverse effects, which may be delayed.
Skin contact Using appropriate personal protective equipment, remove contaminated clothing and flush
exposed area with large amounts of soap and water. Obtain medical attention if skin reaction
occurs, which may be immediate or delayed.
Eye contact Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain
medical attention.
Fire-fighting measures
Extinguishing Media No special requirements needed. Water is recommended for fires involving packaging.
Special Firefighting Procedures
Since toxic, corrosive or flammable vapours might be evolved from fires involving this material,
self contained breathing apparatus and full protective equipment are recommended for
firefighters.
Move containers from the fire area if possible without increased personal risk.
If possible, contain and collect firefighting water for later disposal.
Special Firefighting Procedures
Since toxic, corrosive or flammable vapours might be evolved from fires involving this material,
self contained breathing apparatus and full protective equipment are recommended for
firefighters.
Move containers from the fire area if possible without increased personal risk.
If possible, contain and collect firefighting water for later disposal.
Accidental release measures
Personal Precautions Fence or cordon the affected area and do not allow individuals to touch or walk through the
spilled material unless wearing appropriate protective clothing. Avoid dust generation.
Environmental Precautions Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If
spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain.
Clean-up Methods Collect and place it in a suitable, properly labelled container for recovery or disposal. After all
solid or absorbent material has been collected, the area should be vacuumed with HEPA
filter-equipped apparatus.
Decontamination Procedures No specific decontamination or detoxification procedures have been identified for this material.
Consider use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of
this SDS), for clean-up and decontamination operations.
spilled material unless wearing appropriate protective clothing. Avoid dust generation.
Environmental Precautions Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If
spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain.
Clean-up Methods Collect and place it in a suitable, properly labelled container for recovery or disposal. After all
solid or absorbent material has been collected, the area should be vacuumed with HEPA
filter-equipped apparatus.
Decontamination Procedures No specific decontamination or detoxification procedures have been identified for this material.
Consider use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of
this SDS), for clean-up and decontamination operations.
Handling and storage
General Requirements Avoid dispersion as a dust cloud.
Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended
to provide routine control of fire and explosion hazards during handling of this material.
Ignition Controls Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are
present. Isolated conductors can accumulate sufficient electrostatic charge to produce
discharges of many hundreds of milli-Joules.
Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated)
human body can readily produce electrostatic discharges in excess of 50 mJ, but have been
recorded up to 100 mJ.
Minimise the use of plastics when handling this material.
The maximum surface temperature of enclosures potentially exposed to this material should be
the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust
cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum
temperature of 325 °C.
Protective Systems Assess operations based upon available dust explosion information to determine the suitability of
preventive or protective systems as precautionary measures against possible dust explosions. If
prevention is not possible, consider protection by use of containment, venting or suppression of
dust handling equipment. Where explosion venting is considered the most appropriate method of
protection, vent areas should preferably be calculated based on the Kst rather than the St value.
If nitrogen purging is considered as the protective system, it must operate with an oxygen level
below the limiting oxygen concentration. The system should include an oxygen monitoring and
shut-down facility in the event of excessive oxygen being detected.
At both ambient and low humidity, this material is of low conductivity. Generation of electrostatic
charge is considered likely to occur even when handled in an earthed (grounded) environment.
At both ambient and low humidity, this material has a long charge relaxation time. Accumulation
of electrostatic charge is considered likely to occur even when handled in an earthed (grounded)
environment. Under these conditions, it is considered that this material might present a very high
risk of producing an electrostatic discharge.
STORAGE Keep in tightly closed containers or packages away from moisture and away from sources of
ignition.
Avoid prolonged storage at elevated temperatures (greater than room temperature,
approximately 20 degrees C).
Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended
to provide routine control of fire and explosion hazards during handling of this material.
Ignition Controls Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are
present. Isolated conductors can accumulate sufficient electrostatic charge to produce
discharges of many hundreds of milli-Joules.
Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated)
human body can readily produce electrostatic discharges in excess of 50 mJ, but have been
recorded up to 100 mJ.
Minimise the use of plastics when handling this material.
The maximum surface temperature of enclosures potentially exposed to this material should be
the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust
cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum
temperature of 325 °C.
Protective Systems Assess operations based upon available dust explosion information to determine the suitability of
preventive or protective systems as precautionary measures against possible dust explosions. If
prevention is not possible, consider protection by use of containment, venting or suppression of
dust handling equipment. Where explosion venting is considered the most appropriate method of
protection, vent areas should preferably be calculated based on the Kst rather than the St value.
If nitrogen purging is considered as the protective system, it must operate with an oxygen level
below the limiting oxygen concentration. The system should include an oxygen monitoring and
shut-down facility in the event of excessive oxygen being detected.
At both ambient and low humidity, this material is of low conductivity. Generation of electrostatic
charge is considered likely to occur even when handled in an earthed (grounded) environment.
At both ambient and low humidity, this material has a long charge relaxation time. Accumulation
of electrostatic charge is considered likely to occur even when handled in an earthed (grounded)
environment. Under these conditions, it is considered that this material might present a very high
risk of producing an electrostatic discharge.
STORAGE Keep in tightly closed containers or packages away from moisture and away from sources of
ignition.
Avoid prolonged storage at elevated temperatures (greater than room temperature,
approximately 20 degrees C).
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- Not Regulated for Transportation
Shippingopen allclose all
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- Not Regulated for Transportation
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- Not Regulated for Transportation
Shipping information
- Proper shipping name and description:
- Not Regulated for Transportation
- Chemical name:
- Not Regulated for Transportation
- Labels:
- Not Regulated for Transportation
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- Not Regulated for Transportation
Shipping information
- Proper shipping name and description:
- Not Regulated for Transportation
- Chemical name:
- Not Regulated for Transportation
- Labels:
- Not Regulated for Transportation
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
OCCUPATIONAL EXPOSURE LIMITS
GSK Occupational Hazard Category 3 SKIN SENSITISER
ENGINEERING CONTROLS
Exposure Controls The hygiene guide for this material is >10 to 100 mcg/m3. An Exposure Control Approach (ECA)
is established for operations involving this material based upon the OEL/Occupational Hazard
Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure
Control Matrix for more information about how ECA's are assigned and how to interpret them.
Containment Open handling is not recommended. Consider segregating operations, use of enclosures and
sealed transfer systems.
Ventilation Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a
means of removing material incidentally released.
Administrative Entry to the working area should be controlled. Doors with interlocks may be needed for
materials airlocks and locker rooms. Only equipment and supplies necessary for job activities
should be taken into working area.
PERSONAL PROTECTIVE EQUIPMENT
Eye Protection Wear approved safety glasses with side shields or cover goggles if eye contact is possible.
Gloves The selection of gloves for a specific activity must be based on the material's properties and on
possible permeation and degradation that may occur under the circumstances of use. Glove
selection must take into account any solvents and other hazards present. Potential allergic
reactions can occur with certain glove materials (e.g. Latex) and therefore these should be
avoided. Care must be exercised if insufficient data are available and further guidance should be
sought from your local EHS department.
Respirators If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air
concentrations present, required protection factor as well as hazards, physical properties and
warning properties of substances present.
Other Equipment or
Procedures
Follow all local regulations if personal protective equipment (PPE) is used in the workplace.
Consider control procedures for maintenance, cleaning and emergencies.
GSK Occupational Hazard Category 3 SKIN SENSITISER
ENGINEERING CONTROLS
Exposure Controls The hygiene guide for this material is >10 to 100 mcg/m3. An Exposure Control Approach (ECA)
is established for operations involving this material based upon the OEL/Occupational Hazard
Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure
Control Matrix for more information about how ECA's are assigned and how to interpret them.
Containment Open handling is not recommended. Consider segregating operations, use of enclosures and
sealed transfer systems.
Ventilation Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a
means of removing material incidentally released.
Administrative Entry to the working area should be controlled. Doors with interlocks may be needed for
materials airlocks and locker rooms. Only equipment and supplies necessary for job activities
should be taken into working area.
PERSONAL PROTECTIVE EQUIPMENT
Eye Protection Wear approved safety glasses with side shields or cover goggles if eye contact is possible.
Gloves The selection of gloves for a specific activity must be based on the material's properties and on
possible permeation and degradation that may occur under the circumstances of use. Glove
selection must take into account any solvents and other hazards present. Potential allergic
reactions can occur with certain glove materials (e.g. Latex) and therefore these should be
avoided. Care must be exercised if insufficient data are available and further guidance should be
sought from your local EHS department.
Respirators If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air
concentrations present, required protection factor as well as hazards, physical properties and
warning properties of substances present.
Other Equipment or
Procedures
Follow all local regulations if personal protective equipment (PPE) is used in the workplace.
Consider control procedures for maintenance, cleaning and emergencies.
Stability and reactivity
Conditions to Avoid Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.
Disposal considerations
Disposal Recommendations Collect for recycling or recovery if possible. The recommended method of disposal is
incineration. Wherever possible, disposal should be in an on-site licenced chemical incinerator, if
allowed by the incinerator licence or permit. If no on-site incinerator is available, dispose of
material in a licenced commercial chemical incinerator.
Regulatory Requirements Observe all local and national regulations when disposing of this material.
incineration. Wherever possible, disposal should be in an on-site licenced chemical incinerator, if
allowed by the incinerator licence or permit. If no on-site incinerator is available, dispose of
material in a licenced commercial chemical incinerator.
Regulatory Requirements Observe all local and national regulations when disposing of this material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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