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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Toxic effect type:
dose-dependent

Effects on fertility

Link to relevant study records
Reference
Endpoint:
two-generation reproductive toxicity
Remarks:
based on test type (migrated information)
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
Principles of method if other than guideline:
Data is predicted by QSAR toolbox version 3.1
GLP compliance:
no
Species:
rat
Strain:
Fischer 344
Sex:
male/female
Route of administration:
oral: gavage
Type of inhalation exposure (if applicable):
not specified
Vehicle:
water
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Males: 42 days
Females: 42-48 days (from 14 days before mating to day 4 of lactation)
Frequency of treatment:
Daily
No. of animals per sex per dose:
12 animals per sex per dose
Control animals:
yes, concurrent vehicle
Dose descriptor:
other: not specified
Based on:
not specified
Sex:
not specified
Basis for effect level:
other: not specified
Remarks on result:
other: not specified
Critical effects observed:
not specified
System:
other: not specified
Organ:
not specified
Dose descriptor:
NOAEL
Generation:
F2
Effect level:
521 mg/kg bw/day
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: Body weight; food consumption; organ weights
Remarks on result:
other: not specified
Critical effects observed:
not specified
System:
other: not specified
Organ:
not specified
Reproductive effects observed:
not specified
Treatment related:
not specified

The prediction was based on dataset comprised from the following descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

((((("a" or "b" or "c" or "d" or "e" or "f" )  and ("g" and ( not "h") )  )  and "i" )  and "j" )  and ("k" and "l" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Aliphatic Amines by US-EPA New Chemical Categories

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Group 1 - Alkali Earth Li,Na,K,Rb,Cs,Fr AND Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Carboxylic acid AND Sarcosine by Organic functional groups (nested)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Acid, aliphatic attach [-COOH] AND Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Amino, aliphatic attach [-N<] AND Amino, aliphatic attach [-NH-] AND Carbonyl, aliphatic attach [-C(=O)-] AND Miscellaneous sulfide (=S) or oxide (=O) AND Olefinic carbon [=CH- or =C<] by Organic functional groups (US EPA)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Alpha-aminoacid AND Amine AND Anion AND Carbonic acid derivative AND Carboxylic acid AND Carboxylic acid derivative AND Carboxylic acid salt AND Cation AND Secondary aliphatic amine AND Secondary amine by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Acid, aliphatic attach [-COOH] AND Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Amino, aliphatic attach [-N<] AND Amino, aliphatic attach [-NH-] AND Carbonyl, aliphatic attach [-C(=O)-] AND Miscellaneous sulfide (=S) or oxide (=O) AND Olefinic carbon [=CH- or =C<] by Organic functional groups (US EPA)

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OECD

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Direct Acylation Involving a Leaving group OR Acylation >> Direct Acylation Involving a Leaving group >> Acetates OR Acylation >> Ring Opening Acylation OR Acylation >> Ring Opening Acylation >> alpha-Lactams OR Michael addition OR Michael addition >> Polarised Alkenes OR Michael addition >> Polarised Alkenes >> Polarised alkene - amides OR Michael addition >> Polarised Alkenes >> Polarised alkene - esters by Protein binding by OECD

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (original)

Domain logical expression index: "j"

Similarity boundary:Target: C(=O)(O)C(CCC(=O)O{-}.[Na]{+})NCCCCCCCCCCCC
Threshold=80%,
Dice(Atom pairs)

Domain logical expression index: "k"

Parametric boundary:The target chemical should have a value of log Kow which is >= -2.39

Domain logical expression index: "l"

Parametric boundary:The target chemical should have a value of log Kow which is <= -0.0533

Conclusions:
The two generation reproductive toxicity NOAEL (No observed Adverse effect level) of l-Glutamic acid, N-coco acyl derivs., monosodium salts in rat(Fischer 344)was observed at a dose concentration of 521 mg/kg bw/day.
Executive summary:

The two generation reproductive toxicity NOAEL (No observed Adverse effect level) ofl-Glutamic acid, N-coco acyl derivs., monosodium salts in rat(Fischer 344)was observed at a dose concentration of 521 mg/kg bw/day.This indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts shall not exhibit toxic effect to rat below the above mention dose.

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
521
Study duration:
subacute
Species:
rat
Quality of whole database:
K2 level data from QSAR prediction
Additional information

The two generation reproductive toxicity NOAEL (No observed Adverse effect level) ofl-Glutamic acid, N-coco acyl derivs., monosodium salts in rat(Fischer 344)was observed at a dose concentration of 521 mg/kg bw/day.This indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts shall not exhibit toxic effect to rat below the above mention dose. Similar results have also been observed for different species which confirms that the substance is non toxic to reproduction.

Justification for selection of Effect on fertility via oral route:

The two generation reproductive toxicity NOAEL (No observed Adverse effect level) ofl-Glutamic acid, N-coco acyl derivs., monosodium salts in rat(Fischer 344)was observed at a dose concentration of 521 mg/kg bw/day.This indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts shall not exhibit toxic effect to rat below the above mention dose.

Effects on developmental toxicity

Link to relevant study records
Reference
Endpoint:
developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 414 (Prenatal Developmental Toxicity Study);
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.1
GLP compliance:
not specified
Species:
rat
Strain:
Fischer 344
Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Gestation day 6 - 15
Frequency of treatment:
daily
No. of animals per sex per dose:
20
Control animals:
yes, concurrent no treatment
Dose descriptor:
other: not specified
Based on:
not specified
Basis for effect level:
other: not specified
Remarks on result:
other: not specified
Abnormalities:
not specified
Localisation:
not specified
Description (incidence and severity):
not specified
Dose descriptor:
NOAEL
Effect level:
388.268 mg/kg bw/day
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: fetotoxicity
Remarks on result:
other: not specified
Abnormalities:
not specified
Localisation:
other: not specified
Description (incidence and severity):
not specified
Developmental effects observed:
not specified
Treatment related:
not specified

The prediction was based on dataset comprised from the following descriptors: NOAEL
Estimation method: Takes average value from the 6 nearest neighbours
Domain  logical expression:Result: In Domain

((((("a" and ("b" and ( not "c") )  )  and "d" )  and ("e" and ( not "f") )  )  and "g" )  and ("h" and "i" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Aliphatic Amines by US-EPA New Chemical Categories

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.1

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group >> alpha,beta-carbonyl compounds with polarized double bonds by Protein binding by OASIS v1.1

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Alkali Earth AND Non-Metals by Groups of elements

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Halogens OR Metalloids by Groups of elements

Domain logical expression index: "g"

Similarity boundary:Target: C(=O)(O)C(CCC(=O)O{-}.[Na]{+})NCCCCCCCCCCCC
Threshold=80%,
Dice(Atom pairs)

Domain logical expression index: "h"

Parametric boundary:The target chemical should have a value of log Kow which is >= -1.71

Domain logical expression index: "i"

Parametric boundary:The target chemical should have a value of log Kow which is <= -0.878

Conclusions:
The No Observed Adverse Effect Level fetotoxicity value of l-Glutamic acid, N-coco acyl derivs., monosodium salts in rat was observed at dose concentration of 388.267852783 mg/kg bw/day.
Executive summary:

The No Observed Adverse Effect Level fetotoxicity value of l-Glutamic acid, N-coco acyl derivs., monosodium salts in rat was observed at dose concentration of 388.267852783 mg/kg bw/day .

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
388.26 mg/kg bw/day
Study duration:
subacute
Species:
rat
Quality of whole database:
K2 level data from QSAR prediction
Additional information

The No Observed Adverse Effect Level fetotoxicity value of l-Glutamic acid, N-coco acyl derivs., monosodium salts in rat was observed at dose concentration of 388.267852783 mg/kg bw/day . This indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts shall not exhibit toxic effect to rat below the above mention dose. Similar results have also been observed for different species which confirms that the substance is non toxic to reproduction.

Justification for selection of Effect on developmental toxicity: via oral route:

The No Observed Adverse Effect Level fetotoxicity value of l-Glutamic acid, N-coco acyl derivs., monosodium salts in rat was observed at dose concentration of 388.267852783 mg/kg bw/day .

Justification for classification or non-classification

The prediciton results indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts shall not exhibit toxic effect to animals below the mention dose of the study, which confirms that the substance is non toxic to reproductive organism and will not qualify for classification.

Additional information