Registration Dossier
Registration Dossier
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EC number: 219-669-7 | CAS number: 2494-89-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February to March 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- Internal Guideline Hoechst AG
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-[(p-aminophenyl)sulphonyl]ethyl hydrogensulphate
- EC Number:
- 219-669-7
- EC Name:
- 2-[(p-aminophenyl)sulphonyl]ethyl hydrogensulphate
- Cas Number:
- 2494-89-5
- Molecular formula:
- C8H11NO6S2
- IUPAC Name:
- [2-(4-aminobenzenesulfonyl)ethoxy]sulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): p-Base-Ester
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25g / 100 ml
- Amount of vehicle (if gavage): 5000 mg/kg bw
- Justification for choice of vehicle: provide homogeneous suspension - Doses:
- 5 g/kg body weight
- No. of animals per sex per dose:
- 10 females
- Control animals:
- no
- Details on study design:
- Weight range at start: 164 to 170 g
Test substance concentration: 25%
Withhold of food 16 hours prior to test substance administration
Observation period: 7 days after test substance administration - Statistics:
- Exact determination of LD50 not possible - only one of ten rats died --> LD50 >5000 mg/kg
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- one of 10 rats at 5000 mg/kg died
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50 above 5000 mg/kg bw.
No classification required.
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