Registration Dossier
Registration Dossier
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EC number: 205-286-2 | CAS number: 137-26-8
Endpoint summary
Administrative data
Description of key information
Additional information
Tetramethylthiuram disulfide (CAS No. 137-26-8) is highly toxic to aquatic organisms. Three long-term key studies are available for all three trophic levels (primary producers, primary and secondary consumers). Furthermore, five short-term key studies are available for four trophic levels (primary producers, primary and secondary consumers, and decomposer). Furthermore, two mesocosm studies are available. Both acute and chronic exposure to the tested substance caused lethal and/or sublethal effects at all trophic levels tested in the laboratory.
Fish species showed the highest sensitivity to tetramethylthiuram disulfide (CAS No. 137-26-8) under short-term (LC50 (96 h) = 0.046 mg/L (meas. initial; survival)) and long-term exposure conditions (NOEC (33 d) = 4.6 µg/L measured arith. mean; larval survival, growth). Tetramethylthiuram disulfide (CAS No. 137-26-8) caused effects on mobility and reproduction of aquatic invertebrates in acute and chronic toxicity studies resulting in an EC50 (48 h) of 139 µg/L (mean measured; mobility) and a NOEC (21 d) of 20 µg/L (mean measured; growth). Growth inhibition studies with algae resulted into an ErC50 (72 h) of > 141 µg/L (geometric mean, growth rate) and an ErC10 (72 h) of 56.9 µg/L (geometric mean, growth rate). Furthermore, inhibitory effects were observed on aquatic microorganisms’ total respiration (EC10 (3 h) value of 0.6 mg/L (nominal)). Tetramethylthiuram disulfide (CAS No. 137-26-8) also negatively affected the frond production of aquatic plants, resulting in an IC50 (7 d) of 1.6 mg/L (initial measured) and a NOAEC (7 d) of 0.057 mg/L (initial measured). Mesocosm and microcosm studies, simulating natural conditions in a water/sediment system proved that tetramethylthiuram disulfide (CAS No. 137-26-8) is rapidly degraded under these environmental conditions and therefore, accumulation in water bodies is not expected. The results from these two studies showed that population densities of the water/sediment indigenous communities recovered shortly after exposure to this substance.
All key studies were conducted according to appropriate guidelines and GLP conditions.
An assessment on endocrine disruption was performed during the CoRAP substance evaluation of Thiram. The outcome of this evaluation in 2018 was that Thiram has no ED concern.
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