2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Toxicity of antioxidants to tetrahymena pyriformis

Author:

Epstein SS, Saporoschetz IB, Hutner SH

Year:

1967

Bibliographic source:

J Protozool, Vol. 14 (2), 238-243

Materials and methods

Principles of method if other than guideline:

The cytotoxicity of 97 antioxidants of various structural types, among these the test substance, was determined for Tetrahymena pyriformnis grown in a peptone medium.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol

EC Number:

213-590-1

EC Name:

2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol

Cas Number:

991-84-4

Molecular formula:

C33H56N4OS2

IUPAC Name:

2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol

Results and discussion

Any other information on results incl. tables

The test substance had low toxicity to Tetrahymena pyriformis (median ID50: >1000 µg/ml) and low toxicity to rat (LD50: >5 g/kg bw) as well as high antioxidant activity by the photodynamic test when related to d-a-Tocopherol (value 3.1 for the test substance and 1 for tocopherol).