Registration Dossier
Registration Dossier
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EC number: 227-563-7 | CAS number: 5888-87-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- 48.94 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH value was not determined
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility: ca. 49 mg/L at 20 °C. - Executive summary:
The solubility in water was determined to be:
48.94 ± 1.11 mg/L at 20 ± 0.5 °C.
Reference
In a preliminary study, the solubility of the test item in water could be estimated as Iying between 10 and 100 mg/L, approx. 40 mg/L.
In the main study, 400-410 mg/L were weighed into each of six individual vessels, water was added, and the vessels were shaken at 20 ± 0,5 °C.
On the days 3, 4, 5 and 6, vessel 1 was taken fram the shaking apparatus and stored at 20 ± 0.1 °C for equilibration. Samples were taken, filtrated and analysed using HPLC as shaking of the test vessels was continued.
No differences above 15% in the concentration of the solution could be determined between the sampling dates 1, 2, 3 and 4, supporting the hypothesis, that the maximum concentration of the test item had been reached. Therefore, on day 6, vessels 2 - 6 were
sampled and analysed in the same fashion.
At the plateau, the concentration of N,N'-hexane-1 ,6-diylbis(hexahydro-2-oxo-1 H-azepine-1-carboxamide) in water had reached
48.94 ± 1.11 mg/L at 20 ± 0.5 °C = 4.894 ± 0.111 * 10.5 kg/L (SI units)
(mean value ± standard deviation of six individual vessels)
Description of key information
The substance is sparingly soluble in water.
Key value for chemical safety assessment
- Water solubility:
- 48.94 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility was determined to be: 48.94 ± 1.11 mg/L (at 20 ± 0.5 °C).
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