Registration Dossier
Registration Dossier
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EC number: 610-916-8 | CAS number: 5294-61-1
Endpoint summary
Administrative data
Description of key information
Key study: Test method according to OECD Guideline 420. GLP study. The substance was classified as category 4 according to CLP Regulation (EC) no. 1272/2008 since the dose of 2000 mg/kg bw caused death in the sighting study. No effects were observed at 300 mg/kg bw (main study).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 300 mg/kg bw
- Quality of whole database:
- Klimisch score = 1. GLP study.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Key study: The acute oral toxicity study based on a fixed dose method was performed according to OECD Guideline 420 (GLP study). The experiment commenced with a sighting study in which the test item was first administered to a female rat at a single dose of 300 mg/kg bw but, since no signs of toxicity were observed, a dose of 2000 mg/kg bw was given to a second rat. A slight decrease in locomotor activity and tremors occurred 3 hours post-administration. The animal died on the first day of the observation period. On the grounds of these results, four animals in the main study were given the test item at a dose of 300 mg/kg bw. After the administration of the test item, the animals were observed for 14 days. No signs of toxicity were found and all animals survived the experiment. During the 14-day experiment, body weights of the animals increased. Regarding the gross examinations, no lesions were found in the animals. The substance was classified as category 4 according to CLP Regulation (EC) no. 1272/2008 since the dose of 2000 mg/kg bw caused death in the sighting study.
Justification for selection of acute toxicity – oral endpoint
Only one study available.
Justification for classification or non-classification
Based on the available results the substance is classified for Acute Toxicity Category 4 according to CLP Regulation (EC) no. 1272/2008.
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