Registration Dossier
Registration Dossier
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EC number: 201-089-0 | CAS number: 78-16-0
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC =1000 mg/kg for Eisenia fetida (OECD 222)
Key value for chemical safety assessment
Additional information
A study on the long-term toxicity of 2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS 78-16-0) according to OECD guideline 222 is available. The effect of the test substance on earthworm survival, growth and reproduction was tested in accordance with GLP provisions (Eisner, 2013). The test was conducted with artificial soil that was mixed with the test substance. Earthworms of the species Eisenia fetida were exposed to the test substance for 28 days and then removed from the test substrate. The survival rate and growth (body weight) of the specimen were determined. After another 28 days the hatched juveniles were collected from the test substrate and the reproduction rate was recorded. Mortality or a decrease in body weight of the adult earthworms was not observed. Thus a NOEC 1000 mg/kg soil based on mortality was reported. A NOEC ≥ 1000 mg/kg soil based on the reproduction rate was determined.
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