Propanamide, 2-hydroxy-N,N-dimethyl-

Toxicity to aquatic algae and cyanobacteria

Description of key information

Two acute algae studies according to guideline OECD 201 are availble.
In the first study the test item was tested for toxicity to freshwater algae (Desmodesmus subspicatus)  in 72 h-growth inhibition test. The EC50 was found to be greater than 800 mg/L, the EC10 was found to be 302 mg/l. 
The second study was performed as a limit test with a test concentration of  100 mg/l. The test item was tested for toxicity to freshwater algae (Desmodesmus subspicatus)  in 72 h-growth inhibition test. The EC 10 and EC50 were  found to be >100 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:

100 mg/L

EC10 or NOEC for freshwater algae:

100 mg/L

Additional information

Two studies investigating the toxicity of Propanamide, 2-hydroxy-N,N-dimethy to algae are available.

Both studies were performed according to GLP and OECD guideline 201 using Desmodesmus subspicatus as test organism.

In the first study (Noak, 2009) nominal concentrations between 0.5 and 800 mg/L were tested over a period of 72 h. The 72h-EC50 is determined to be 800 mg/L and the 72h-EC10 is determined to be 302 mg/L based on nominal test concentrations.

In the second study (Clariant, 2008) performed as a limit test with a nominal concentration of 100 mg/l , for growth rate an EC50 and an EC10 of > 100 mg/l were determined.

Since the second study was performed as a limit test with 100 mg/L and for reasons of precausioary principle this values was used as key value for the safety assessment.