Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
Estimation of 21 days NOEC value for long term toxicity to aquatic invertebrates using the ECOSAR version 1.11.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
21 d
Reference substance (positive control):
no
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.144 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
reproduction
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of effect of test chemical observed in a flow-through freshwater system on the reproduction of the test organism during the 21 days exposure period, the NOEC value for the test chemical was estimated to be 0.144 mg/l.
Executive summary:

Based on the prediction done using ECOSAR version 1.11 (2018), the long term toxicity on aquatic invertebrate was predicted for test chemical. On the basis of effect of test chemical observed in a flow-through freshwater system on the reproduction of the test organism during the 21 days exposure period, the NOEC value for the test chemical was estimated to be 0.144 mg/l. Thus, based on this value, test chemical can be considered as toxic to aquatic invertebrates at environmental relevant concentrations.

Description of key information

Based on the prediction done using ECOSAR version 1.11 (2018), the long term toxicity on aquatic invertebrate was predicted for test chemical. On the basis of effect of test chemical observed in a flow-through freshwater system on the reproduction of the test organism during the 21 days exposure period, the NOEC value for the test chemical was estimated to be 0.144 mg/l. Thus, based on this value, test chemical can be considered as toxic to aquatic invertebrates at environmental relevant concentrations.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.144 mg/L

Additional information

Based on the prediction done using ECOSAR version 1.11 (2018), the long term toxicity on aquatic invertebrate was predicted for test chemical. On the basis of effect of test chemical observed in a flow-through freshwater system on the reproduction of the test organism during the 21 days exposure period, the NOEC value for the test chemical was estimated to be 0.144 mg/l. Thus, based on this value, test chemical can be considered as toxic to aquatic invertebrates at environmental relevant concentrations.