Registration Dossier
Registration Dossier
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EC number: 609-664-1 | CAS number: 393-85-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Guideline B.1, Acute Oral toxicity in Council Directive 84/449/EEC
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 5-Fluoro-2-nitrobenzoic acid methyl ester
- EC Number:
- 609-664-1
- Cas Number:
- 393-85-1
- Molecular formula:
- C8H6FNO4
- IUPAC Name:
- 5-Fluoro-2-nitrobenzoic acid methyl ester
- Test material form:
- other: yellow liquid
- Details on test material:
- purity: 96.9 % +/-0.2 %, storage: darkness at room temperature in a fume cupboard
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Strain: Hoe: WISKf (SPF71), Animal Source : Hoechst AG, Kastengrund, SPF breeding colony, age at the start of the experiment: males: 7 weeks, females: 8 weeks
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- The animals received the compound as a 20 % solution in sesame oil, the application volume was 10 ml/kg bw
- Doses:
- 500 mg/kg bw, 1000 mg/kg bw, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per group
- Details on study design:
- Behaviour and state of health were observed daily in all groups. Body weight and food consumption
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- No deaths occourred during the whole study.
- Clinical signs:
- other: No symptoms were observed after application of 2000 mg/kg bw.
- Gross pathology:
- No macroscopically changes were visible.
- Other findings:
- The animals killed at the end of the observation period showed no macroscopically visible changes.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute toxicity testing of 5-Fluoro-2-nitrobenzoic acid methyl ester in the Wistar rat yield a median lethal dose above 2000 mg/kg bw in male and female animals. After application of 2000 mg/kg bw neither death nor symptomes occurred.
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