Registration Dossier
Registration Dossier
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EC number: 202-451-0 | CAS number: 95-78-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from Danish QSAR
Data source
Reference
- Reference Type:
- other: Predicted database
- Title:
- Danish QSAR study for the CAS 95-78-3
- Author:
- Danish (Q)SAR Database
- Year:
- 2 019
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- The data predicted using the Danish (Q)SAR Database
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,5-xylidine
- EC Number:
- 202-451-0
- EC Name:
- 2,5-xylidine
- Cas Number:
- 95-78-3
- Molecular formula:
- C8H11N
- IUPAC Name:
- 2,5-dimethylaniline
- Reference substance name:
- 2, 5-xylidine
- IUPAC Name:
- 2, 5-xylidine
- Details on test material:
- - Name of test material: 2, 5-xylidine
- Molecular formula: C8H11N
- Molecular weight: 121.18
- Substance type: Organic
- Physical state: Liquid
- Analytical purity: >=97%
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period:
- not specified
- Number of animals:
- not specified
- Details on study design:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- not specified
- Other effects:
- not specified
Any other information on results incl. tables
Table showing skin irritation estimation by four different models i.e, Battery,SciQSAR ,CASE Ultra
and Leadscope.The average skin irritation results was given by the first model i.e, Battery model.
DK |
Battery |
Ultra Leadscope |
Leadscope |
SciQSAR |
Skin irritation in rabbit |
NEG_IN |
NEG_IN |
NEG_IN |
INC_OUT |
Domain |
IN |
IN |
IN |
OUT |
Where,
IN = inside applicability domain
OUT = outside applicability domain
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No severe skin irritation effects of the test chemical were estimated in rabbit skin by three different models i.e, Battery, Leadscope and CASE Ultra used within Danish QSAR database.
- Executive summary:
Skin irritation effects were estimated by three different models i.e, Battery, Leadscope and CASE Ultra used within Danish QSAR database for the test chemical. Based on estimation, No severe skin irritation effects were known when the test chemical was exposed to rabbit skin.
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