2,5-xylidine

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database and seconday source

Qualifier:

according to guideline

Guideline:

other: Bioaccumulation test of a chemical substance in fish or shellfish provided in the Notice on the Test Method Concerning New Chemical Substances

Principles of method if other than guideline:

To determine bioaccumulation of test chemical

GLP compliance:

not specified

Test organisms (species):

Cyprinus carpio

Details on test organisms:

- Common name: common carp
- Length at study initiation: 8 cm

Route of exposure:

aqueous

Test type:

static

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

6 wk

Nominal and measured concentrations:

1st Concentration area: 1 mg/L,
2nd Concentration area: 0.1 mg/L

Lipid content:

3.7 %

Time point:

start of exposure

Key result

Conc. / dose:

1 mg/L

Type:

BCF

Value:

1.5 L/kg

Basis:

whole body w.w.

Time of plateau:

6 wk

Remarks on result:

other: No other data available

Conc. / dose:

0.1 mg/L

Type:

BCF

Value:

3.8 <= L/kg

Basis:

whole body w.w.

Time of plateau:

6 wk

Remarks on result:

other: No other data available

Bioaccumulation test results

		2W	3W	4W	6W
1st Concentration area	Test substance concentration (mg/L)	0.964	0.955	0.960	0.970
	Bioconcentration factor (L/kg)	2.6	2.0	2.6	1.5
		3.2	1.7	2.4	1.8
2nd Concentration area	Test substance concentration (mg/L)	0.0956	0.0950	0.0986	0.101
	Bioconcentration factor (L/kg)	<= 3.8	<= 3.8	<= 3.8	<= 3.8
		<= 3.8	<= 3.8	<= 3.8	<= 3.8

Validity criteria fulfilled:

not specified

Conclusions:

The Bioaccumulation factor (BCF) for the substance was determined to be at 1.5 L/kg for 1 mg/L and <= 3.8 L/kg for 0.1 mg/L

Executive summary:

Study was conducted to determine the bioaccumulation of test chemical in Cyprinus carpio. After the exposure of test chemical with Cyprinus carpio, it was observed that the chemical is non-bioaccumulative as BCF was deteremined to be 1.5 L/kg for 1 mg/L

Description of key information

The Bioaccumulation factor (BCF) for the substance was determined to be at 1.5 L/kg for 1 mg/L and<= 3.8 L/kg for 0.1 mg/L

 

Additional information

Following study includes experimental study for the target chemical to observe the bioconcentration of test chemical.

Study (J-check) was conducted to determine the bioaccumulation of test chemical in Cyprinus carpio. After the exposure of test chemical with Cyprinus carpio, it was observed that the chemical is non-bioaccumulative as BCF was deteremined to be at 1.5 L/kg for 1 mg/L and <= 3.8 L/kg for 0.1 mg/L