Registration Dossier
Registration Dossier
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EC number: 202-046-9 | CAS number: 91-17-8
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- alpha2u-globulins in the urine of male rats: a reliable indicator for alpha2u-globulin accumulation in the kidney
- Author:
- Saito K, Uwagawa S, Kaneko H, Shiba K, Tomigahara Y and Nakatsuka I
- Year:
- 1 996
- Bibliographic source:
- Toxicology 106, 149-157
Materials and methods
- Type of study / information:
- Type: other: Nephrotoxicity
- Principles of method if other than guideline:
- experimental study
- GLP compliance:
- no
Test material
- Reference substance name:
- Decalin
- IUPAC Name:
- Decalin
- Details on test material:
- Decahydronaphthalene, no data on purity or isomer ratio
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Decahydronaphthalene was shown to induce increased concentration of urinary alpha-2u-globulin associated with alpha-2u-globulin concentration in the kidney.
- Executive summary:
Marked elevation of urinary kidney-type-alpha 2u-globulin (alphaG-K, molecular weight approximately 16 kDa) was noted following oral treatment of adult male rats with decahydronaphthalene by gavage (1.5 mmol/kg/day) for 7 consecutive days, in association with increased concentrations of renal alphaG-K and hyaline droplet accumulation in renal proximal convoluted tubule epithelial cells.
The findings in this study thus indicate that measurement of urinary alphaG-K can give a reliable estimates not only of the potential to cause renal accumulation of alpha-2u-globulin but also of its magnitude.
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