Registration Dossier
Registration Dossier
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EC number: 288-003-5 | CAS number: 85631-54-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-10-01 until 1989-10-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Perfluoroalkylethylacrylate
- IUPAC Name:
- Perfluoroalkylethylacrylate
- Reference substance name:
- 2-Propenoic acid, γ-ω-perfluoro-C8-14-alkyl esters
- EC Number:
- 288-003-5
- EC Name:
- 2-Propenoic acid, γ-ω-perfluoro-C8-14-alkyl esters
- Cas Number:
- 85631-54-5
- Molecular formula:
- C11H7F13O2 - C17H7F25O2
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl prop-2-enoate; 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl prop-2-enoate; 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl prop-2-enoate; 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,14-pentacosafluorotetradecyl prop-2-enoate
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- Three
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- none described
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritant according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- Based on the results of this 4h patch treatment of the rabbit skin the test item is concluded to be not irritant to the skin.
- Executive summary:
The primary skin irritation potential of the test item was investigated according to Guidline OECD 404. The test substance was applied by topical application of 0.5 ml to the rabbit skin. The duration of the skin was 4 hours. The scoring of skin reactions was performed 30 to 60 minutes, 24, 48 and 72 hours after removal of the patch. The mean score was calculated separately for each animal across 3 times (24, 48 and 72 hours after patch removal) for erythema and oedema grades, respectively. The individual mean erythema and oedema scores of the three animals were 0.00, 0.00, and 0.00, respectively.
Based on the results of this 4h patch treatment of the rabbit skin the test item is concluded to be not irritant to the skin.
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