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EC number: 288-003-5 | CAS number: 85631-54-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The bioaccumulation and biotransformation of the 8:2 fluorotelomer acrylate was investigated in rainbow trout via dietary exposure.
Very low levels of the 8:2 FTAc were detected in the internal tissues and feces, suggesting that the 8:2 FTAc was rapidly biotransformed in the gut or liver. Similarly, low concentrations of the 8:2 fluorotelomer alcohol (FTOH) were accumulated in the fish tissues.
Key value for chemical safety assessment
Additional information
In one key study Butt et al. published the biotransformation of the 8:2 fluorotemoler acrylate in rainbow trout. The bioaccumulation and biotransformation of the 8:2 fluorotelomer acrylate was investigated in rainbow trout via dietary exposure. Very low levels of the 8:2 FTAc were detected in the internal tissues and feces, suggesting that the 8:2 FTAc was rapidly biotransformed in the gut or liver. Similarly, low concentrations of the 8:2 fluorotelomer alcohol (FTOH) were accumulated in the fish tissues. In a second publication Butt et al show showed that the 8:2 FTAc is rapidly biotransformed in the liver and stomach S9 fractions, with formation of the 8:2 FTOH observed within 30s to 1 min of incubation.
A supporting study with the read across substance 8:2 FTOH (main degradation product) published by MITI showed that the BCF of 8: FTOH is between 200 – 1100 (Test Concentration - 1st Concentration: 10 microg/L) or between 87 – 310 (Test Concentration - 2nd Concentration: 1 microg/L)
Brandsma: Dietary exposure of rainbow trout to PFOSA does not result in a significant accumulation of PFOSA (BMF of 0.023). The presence of PFOS showed that rainbow trout is able to metabolize PFOSA into PFOS. Half-lives of PFOSA and PFOS were 6.0 ± 0.4 and 16.9 ± 2.5 d, respectively. The fluorotelomer alcohols 8:2 FTOH and 10:2 FTOH are also rapidly metabolized to the fluorotelomer acids (8:2 FTCA, 10:2 FTCA) and the unsaturated acids (8:2 FTUCA, 10:2 FTUCA), respectively. Half-lives were 3.7 ± 0.4, 2.1 ± 0.5, 3.3, and 1.3 d for 10:2 FTCA, 10:2 FTUCA, 8:2 FTCA, and 8:2 FTUCA, respectively. Small quantities of PFOA and PFDA were also detected in rainbow trout exposed to 8:2 and 10:2 FTOH. The results indicate that the neutral precursors studied are rapidly transformed and eliminated by fish while their transformation products are generally more bioaccumulative.
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