Registration Dossier
Registration Dossier
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EC number: 200-064-1 | CAS number: 50-78-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: BPL not indicated
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity on 113 environmental chemicals
- Author:
- Hasegawa R. et al.
- Year:
- 1 989
- Bibliographic source:
- Sci. Rep.Res.Inst. Tohoku Univ., -C, Vol. 36, N° 1-4, 1989, pp 10-16
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- O-acetylsalicylic acid
- EC Number:
- 200-064-1
- EC Name:
- O-acetylsalicylic acid
- Cas Number:
- 50-78-2
- Molecular formula:
- C9H8O4
- IUPAC Name:
- 2-acetoxybenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Commercial source
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1 week acclimation of 5 weeks animals
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- administration 16 hours afetr feed deprivation
- Doses:
- 6 doses:
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 850 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 600
- Based on:
- test mat.
Any other information on results incl. tables
Also tested on male Sprague Dawley with arabic gum: LD50 = 1900 (1660 -2200)
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In a well conducted LD50 study with wistar rats male(10) per dose / 6 doses and female (10), there is a slight difference between sexes (m1850 /f1600) leading by statistical analysis to a mean LD50 of 1725 mg/kg
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