Registration Dossier
Registration Dossier
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EC number: 202-050-0 | CAS number: 91-21-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, available as unpublished report, restrictions in reporting (available report is a summary) but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2,3,4-tetrahydroisoquinoline
- EC Number:
- 202-050-0
- EC Name:
- 1,2,3,4-tetrahydroisoquinoline
- Cas Number:
- 91-21-4
- Molecular formula:
- C9H11N
- IUPAC Name:
- 1,2,3,4-tetrahydroisoquinoline
- Details on test material:
- - Name of the test substance used in the study report: 1,2,3,4-Tetrahydroisoquinoline
- pH (undiluted): ca. 8
- Test substance number: 05/0797-1
- Batch number: LJ 32741/75
Constituent 1
Test animals
- Species:
- other: Human skin model EpiDerm™
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 3 min and 1 h
- Number of animals:
- 2 tissue replicates per treatment
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 47
- Remarks on result:
- other:
- Remarks:
- Time point: 3 minutes. Max. score: 100.0. (migrated information)
- Irritation / corrosion parameter:
- other: other: viability
- Value:
- 14
- Remarks on result:
- other:
- Remarks:
- Time point: 1 hour. Max. score: 100.0. (migrated information)
In vivo
- Irritant / corrosive response data:
- Viability results (% relative to negative control):
- test material: 47% and 14% upon exposure for 3 minutes and 1 hour, respectively.
- positive control: 20% and 9% upon exposure for 3 minutes and 1 hour, respectively.
Evaluation: corrosive
The test method does not yet allow for the dffferentlation of severity of the effect The results however indicate moderate corrosivity (EC: R 34, GHS: subcategory 1B). For final assignment of a risk phrase at present, further evidence or results from an in vlvo study would be needed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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