Registration Dossier
Registration Dossier
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EC number: 238-270-9 | CAS number: 14324-55-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Predates GLP and OECD guidelines, minor restrictions, available as unpublished report
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- No method guideline specified
- GLP compliance:
- no
- Type of study:
- patch test
Test material
- Reference substance name:
- Zinc bis(diethyldithiocarbamate)
- EC Number:
- 238-270-9
- EC Name:
- Zinc bis(diethyldithiocarbamate)
- Cas Number:
- 14324-55-1
- Molecular formula:
- C10H20N2S4Zn
- IUPAC Name:
- zinc bis(diethyldithiocarbamate)
- Details on test material:
- Name of test material (as cited in study report): Ethasan
Constituent 1
In vivo test system
Test animals
- Species:
- human
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Dimethylphtalate
- Concentration / amount:
- Tested as 50% w/v in Dimethylphtalate
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Dimethylphtalate
- Concentration / amount:
- Tested as 50% w/v in Dimethylphtalate
- No. of animals per dose:
- 50 human volunteers
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: Skin changes accompanying application No. 1 through 15
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 1
- Total no. in group:
- 50
- Clinical observations:
- Slight erythema
- Reading:
- other: Challenge
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 0
- Total no. in group:
- 50
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
