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EC number: 238-270-9 | CAS number: 14324-55-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- OECD guideline study, published in literature, minor restrictions in reporting, but otherwise adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Slight modifications
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Details on test conditions:
- TEST SYSTEM
The stock solutions were prepared fresh each day. The test solutions were renewed daily.
TEST MEDIUM / WATER PARAMETERS
- Detailed information about the chemical composition of the media is given elsewhere (Van Leeuwen and Maas, 1985). - Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.24 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 0.20-0.29
Reference
Description of key information
The 48-h EC50 of 0.24 mg/L in Daphnia magna is used in the assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.24 mg/L
Additional information
Two short-term toxicity studies with Daphnia magna are available for zinc diethyldithiocarbamate. A non-GLP, OECD 202 guideline study is available (van Leeuwen et al., 1985a; van Leeuwen, 1986). The test is semi-static without analytical monitoring. The 48-h EC50 value is 0.24 mg/L in Daphnia magna.
Another study is a static GLP-compliant, EPA-660/3-75-009 guideline study without analytical monitoring (Analytical Bio-Chemistry Laboratories, Inc., 1983d). The 48-h EC50 value in Daphnia magna is 0.44 mg/L.
The 48-h EC50 of 0.24 mg/L is the most critical value and is therefore used for assessment.
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