Zinc bis(diethyldithiocarbamate)

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Justification for type of information:

Please find the attached justification.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Key result

Parameter:

% degradation (O2 consumption)

Value:

2

Sampling time:

28 d

Remarks on result:

other: Results from read-across source ZDBC

Key result

Parameter:

% degradation (CO2 evolution)

Value:

7.7

Sampling time:

28 d

Remarks on result:

other: Results from read-across source ZDMC

Interpretation of results:

not readily biodegradable

Reference 2

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Supplementary estimation of ready biodegradability using BIOWIN v4.10

Principles of method if other than guideline:

BIOWIN v4.10 prediction for readily biodegradation.

GLP compliance:

no

Specific details on test material used for the study:

- SMILES: CCN(CC)C(=S)S[Zn]SC(=S)N(CC)CC

Parameter:

probability of ready biodegradability (QSAR/QSPR)

Remarks:

Biowin2 (Non-Linear Biodeg Probability)

Value:

0.106

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Remarks:

Substance falls within the applicable domain of the model.

Parameter:

probability of ready biodegradability (QSAR/QSPR)

Remarks:

Biowin6 (MITI Non-Linear Biodeg Probability)

Value:

0.002

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Remarks:

Substance falss within the applicable domain of the model.

Details on results:

A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable

Table: BIOWIN 4.10 results of the separate models

Endpoint	Result
Biowin1 (Linear Model Prediction)	Biodegrades Fast
Biowin2 (Non-Linear Model Prediction)	Does Not Biodegrade Fast
Biowin3 (Ultimate Biodegradation Timeframe)	Weeks-Months
Biowin4 (Primary Biodegradation Timeframe)	Days-Weeks
Biowin5 (MITI Linear Model Prediction)	Not Readily Degradable
Biowin6 (MITI Non-Linear Model Prediction)	Not Readily Degradable
Biowin7 (Anaerobic Model Prediction)	Biodegrades Fast
Ready Biodegradability Prediction	NO

The test substance falls within the applicable domain of the model (Appendix D of the On-Line BIOWIN(TM) User's Guide).

Please refer to the full results report attached to this IUCLID record.

Interpretation of results:

not readily biodegradable

Description of key information

Zinc bis(diethyldithiocarbamate) is characterised as “not readily biodegradable”.

Key value for chemical safety assessment

Biodegradation in water:

under test conditions no biodegradation observed

Additional information

No ready biodegradation study is available for zinc bis(diethyldithiocarbamate). However, data from the structural analogues zinc bis(dibutyldithiocarbamate) and zinc bis(dimethyldithiocarbamate) will be used instead (see read-arcoss justification in Appendix A). A GLP-compliant OECD 301F test (Manometric Respirometry Test) is available for zinc bis(dibutyldithiocarbamate). After 28 days 2% degradation was observed (Currenta GmbH & Co. OHG, 2010d). For zinc bis(dimethyldithiocarbamate) non-GLP OECD 301B test (CO2 Evolution Test) is available. After 28 days 7.7% degradation was observed ( Monego, J.G, 2007). Therefore, in the assessment zinc bis(diethyldithiocarbamate) is characterised as “not readily biodegradable”. Based on these results, zinc bis(diethyldithiocarbamate) is considered not readily biodegradable.

As supporting information, BIOWIN v4.10 data was generated on the test substance as part of a weight-of-evidence approach. The QSAR model predicts that the substance is not readily biodegradable. As the substance falls within the applicable domain, the results can still be used to support the outcome of the read-across. Therefore, the substance is considered not readily biodegradable.