Registration Dossier
Registration Dossier
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EC number: 618-883-1 | CAS number: 92878-95-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 14-17 July 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431 In vitro skin Corrosion: Human skin model test
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
- EC Number:
- 618-883-1
- Cas Number:
- 92878-95-0
- Molecular formula:
- C10H12ClNO4
- IUPAC Name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
Constituent 1
Test animals
- Species:
- other: In vitro assay in tissue (EpiDerm Skin Model)
Test system
- Number of animals:
- na
Results and discussion
In vivo
- Other effects:
- The relative mean tissue viability obtained after the 3-minute and 1-hour treatments with WAY-188471 compared to the negative control tissues was 100% and 108% respectively. Because the mean relative tissue viability for WAY-188471 was not below 50% after 3 minutes treatment and not below 15% after 1 hour treatment WAY-188471 is considered to be not corrosive
Any other information on results incl. tables
The relative mean tissue viability obtained after the 3-minute and 1-hour treatments with WAY-188471 compared to the negative control tissues was 100% and 108% respectively. Because the mean relative tissue viability for WAY-188471 was not below 50% after 3 minutes treatment and not below 15% after 1 hour treatment WAY-188471 is considered to be not corrosive
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Conclusions:
- Finally, it is concluded that this test is valid and that WAY-188471 is not corrosive in the in vitro skin corrosion test under the experimental conditions described in this report.
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