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Partition coefficient

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Description of key information

Partition coefficient (OECD 117, HPLC method): Pow > 2.5 x 10E9, logPow > 9.4 at 30 °C (read-across from supporting substance '1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol').
For purpose of exposure assessment calculations, a logKow of 8.0 was taken into consideration, since this value represents the maximum valid logKow value in the algorithms of EUSES or EU-TGD approach.

Key value for chemical safety assessment

Log Kow (Log Pow):
8
at the temperature of:
20 °C

Additional information

The partition coefficient of log Pow >9.4 (at 30 °C) was determined on the supporting substance '1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol' by High Performance Liquid Chromatography (HPLC) according to OECD 117 / EU Method A.8, whereby it is safe to say that the partition coefficient of the long-chain homologue '1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-dodecanethiol’ will also be at least > 9.4.

The GLP guideline study on the closely related substance was assigned a reliability score of 2 and considered adequate for assessment as a stand alone study. For purpose of exposure assessment calculations, a logPow of 8.0 was taken into consideration, since this value represents the maximum valid logPow value in the algorithms of EUSES or EU-TGD approach.