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Description of key information

Repeated dose toxicity: oral: Key study: 4-month study in rats: Test method similar to OECD guideline 408. The NOEL was determined as 4000 ppm (approximately 365 mg/kg bw/day). 
Repeated dose toxicity: oral: Key study: 90-day study in dogs: Test method similar to OECD 409 guideline, but only three animals of each sex were used per dose. Based on the results, the no effect level in this study was 500 ppm (approximately 30 mg/kg bw/day).
Repeated dose toxicity: oral: Key study: 2-year study in rats: Test method similar to OECD guideline 452. The NOEL was determined as 1600 ppm (approximately 80 mg/kg bw/day).
Repeated dose toxicity: dermal: supporting study: 5-day study in rats. The NOAEL was greater or equal than 900 mg/kg bw/day (nominal). Experimental design according to HAZARDOUS Substances, Part 191, Section 11, FDA, Washington 1965.

Key value for chemical safety assessment

Additional information

Repeated dose toxicity: oral. Key studies: experimental results with the substance sodium trichloroacetate.

In a 90-day study with dogs, from 2000 ppm upwards effects were observed in mortality, body weights, haematology, urinalysis, gross pathology and histopathology. Therefore, the NOEL was determined to be 500 ppm (approximately 30 mg/kg bw/day).

In a 4-month study with rats, the NOEL was determined to be 4000 ppm (approximately 365 mg/kg bw/day), based on body weight reduction observed at 10000 ppm.

In a 2-year study in rats, the NOEL was determined as 1600 ppm (approximately 80 mg/kg bw/day), based on a significantly body weight reduction observed at 10000 ppm.

 

Justification for classification or non-classification

Based on the results obtained in the different repeated dose toxicity studies, the substance is not classified for specific target organ toxicity.