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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Limited methodological detail is provided; however the study is considered to be sufficiently reliable for the purposes of classification and labelling.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
2-trifluoromethylbenzoyl chloride was administered via microcylinder through a stomach tube. Syptoms were observed for 8 hours and deaths, symptoms and body weight were noted for 7 days. The median lethal dose (LD50) was calculated by the method of Litchfield and Wilcoxon as the standard of mortality to 72 hours following the administration.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Wistar
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 7 weeks old
- Acclimation period: 1 week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 1
- Humidity (%): 55 +/- 5
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 1.5 ml/g body weight
Doses:
0.5-1.5 ml/g body weight
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: once daily
- Necropsy of survivors performed: no
Statistics:
The median lethal dose (LD50) was calculated by the method of Litchfield and Wilcoxon
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 200 mg/kg bw
Based on:
test mat.
95% CL:
7 000 - 9 500
Mortality:
No data
Clinical signs:
other: Decreased movement and 'weakness' were observed and resolvd within 3 days.
Gross pathology:
No data
Other findings:
No data

No data

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for 2-trifluoromethylbenzoyl chloride is 8200 mg/kg bw therefore it is not classified according to Regulation (EC) No 1272/2008
Executive summary:

The results of this study indicate low acute oral toxicity of 2-trifluoromethylbenzoyl chloride in the rat. Based on an LD50 value of 8200 mg/kg bw, the substance does not require classification according to the CLP Regulation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
8 200 mg/kg bw
Quality of whole database:
Limited methodological detail is provided; however the study is considered to be sufficiently reliable for the purposes of classification and labelling.

Additional information

Justification for selection of acute toxicity – oral endpoint
Only one stusy is avaialable.

Justification for classification or non-classification