Registration Dossier
Registration Dossier
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EC number: 255-848-6 | CAS number: 42487-72-9
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test material
- Reference substance name:
- 2-(diethylamino)-6-methyl-1H-pyrimidin-4-one
- EC Number:
- 255-848-6
- EC Name:
- 2-(diethylamino)-6-methyl-1H-pyrimidin-4-one
- Cas Number:
- 42487-72-9
- Molecular formula:
- C9H15N3O
- IUPAC Name:
- 2-(diethylamino)-6-methyl-1,4-dihydropyrimidin-4-one
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Duration of treatment / exposure:
- Five days/week for two weeks
- Details on study design:
- 10 males and 10 female rats were dosed with 100 mg/kg or 400 mg/kg
Examinations
- Sacrifice and pathology:
- No toxic signs. No abnormalities were revealed on post mortem or histopathological examination.
- Other examinations:
- There was no significan anaemia, but reticulocytosis was seen particularly in male rats.
Results and discussion
Results of examinations
- Details on results:
- No toxic signs. No abnormalities were revealed on post mortem or histopathological examination.
There was no significan anaemia, but reticulocytosis was seen particularly in male rats.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- > 400 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No toxic signs were seen. Therefore the NOEC is > 400 mg/kg.
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