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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No study according to current Guidelines but meets scientific standards with acceptable restrictions (partly limited documentation, e.g. no details about the test substance; 24 h exposure)

Data source

Reference
Reference Type:
publication
Title:
The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits
Author:
Flickinger CW
Year:
1976
Bibliographic source:
Am Ind Hyg Assoc J 37: 596-606

Materials and methods

Principles of method if other than guideline:
FHSA method of August 12, 1961, pages 7333-7341
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenol
EC Number:
203-632-7
EC Name:
Phenol
Cas Number:
108-95-2
Molecular formula:
C6H6O
IUPAC Name:
phenol
Details on test material:
Source: Fisher Scientific company, catalogue no. A91, phenol
No further data

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no details available

Test system

Type of coverage:
not specified
Preparation of test site:
other: abraded or intact
Vehicle:
physiological saline
Controls:
not required
Amount / concentration applied:
test substance moistened with physiological saline
Duration of treatment / exposure:
24 h
Observation period:
up to 72 h after exposure
Number of animals:
6
Details on study design:
intact or abraded areas of the skin of the bellies of rabbits exposed for a maximum period of 24 hours;
no further details

Results and discussion

In vivo

Results
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: necrosis of the intact skin; scoring estimated from description of effects
Irritant / corrosive response data:
no further details available
Other effects:
no data about systemic effects

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
Corrosive properties in rabbits after application of 0.5 g to the intact skin and max. exposure duration of 24 h.
Executive summary:

No study according to current Guidelines but meets scientific standards with acceptable restrictions (partly limited documentation, e.g. no details about the test substance; 24 h exposure).

Six rabbits received 0.5 g phenol moistened with physiological saline to the intact or abraded skin of the belly (exposure period max. 24 h and scoring 24 and 72 after exposure. Since the material produced necrosis of the intact skin, it is classified by the authors as a corrosive substance.

Conclusion: Corrosive properties in rabbits after application of 0.5 g to the intact skin and max. exposure duration of 24 h.