Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-002-3 | CAS number: 5205-93-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: QSPR
- Remarks:
- Based on an established human skin model by Potts and Guy (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
- GLP compliance:
- no
Test material
- Reference substance name:
- N-[3-(dimethylamino)propyl]methacrylamide
- EC Number:
- 226-002-3
- EC Name:
- N-[3-(dimethylamino)propyl]methacrylamide
- Cas Number:
- 5205-93-6
- Molecular formula:
- C9H18N2O
- IUPAC Name:
- N-[3-(dimethylamino)propyl]-2-methylacrylamide
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- N-[3-(dimethylamino)propyl]-2-methylacrylamide / 5205-93-6 / 226-002-3, pure substance
Test animals
- Species:
- other: human skin model
- Details on test animals or test system and environmental conditions:
- not applicable; in silico modelling
Administration / exposure
- Type of coverage:
- other: not applicable; in silico modelling
- No. of animals per group:
- not applicable; in silico modelling
Results and discussion
- Absorption in different matrices:
- predicted flux 151.3 μg/cm²/h; the relative dermal absorption is high
Any other information on results incl. tables
Based on a molecular weight of 170.25 g/mol and a g Kow of 0.5, the predicted flux of DMAPMA is 0.351 μg/cm²/h; the relative dermal absorption is low.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of DMAPMA is predicted to be high; the predicted flux is 0.351 μg/cm²/h.
- Executive summary:
The dermal absorption (steady-state flux) of DMAPMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.
Based on a molecular weight of 170.25 g/mol and a logKow of 0.5, the predicted flux of DMAPMA is 0.351 μg/cm²/h; the relative dermal absorption is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
