Registration Dossier
Registration Dossier
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EC number: 238-289-2 | CAS number: 14338-82-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP, only summary available
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only summary available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dibutyl methylenedithiodi(acetate)
- EC Number:
- 238-289-2
- EC Name:
- Dibutyl methylenedithiodi(acetate)
- Cas Number:
- 14338-82-0
- Molecular formula:
- C13H24O4S2
- IUPAC Name:
- butyl 2-({[(2-butoxy-2-oxoethyl)sulfanyl]methyl}sulfanyl)acetate
- Test material form:
- other: liquid
- Details on test material:
- undiluted industrial product, purity >96% w/w
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- 1 animal per cage
body weight 3 to 4 kg
male and female
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 500µl/animal
- Duration of treatment / exposure:
- exposition: 24 h
removing of substance by water, soap and vegetable oil - Observation period:
- 7 days
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Remarks on result:
- other: non irritant
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Remarks on result:
- other: non irritant
- Irritant / corrosive response data:
- no corrosion observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- MBTester is not not irritating to the eyes and the skin.
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