Registration Dossier
Registration Dossier
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EC number: 200-076-7 | CAS number: 51-03-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 4.8
- Temp.:
- 20 °C
- pH:
- 6.5
- Conclusions:
- The determination of the octanol/water partition coefficient of substance test was performed according to EC method A.8, and OECD guideline 117, HPLC Method.
The log Pow was found to be 4.80 (pH = 6.5) at 20°C.
Reference
The test item can be considered as not ionisable because the water solubility showed no pH dependency. Thus a pH dependence of the Pow of substance test was not expected and the partition coefficient was determined only at pH 6.5.
Description of key information
The determination of the octanol/water partition coefficient of substance test was performed according to EC method A.8, and OECD guideline 117, HPLC Method.
Log Pow at 20 °C and pH of 6.5 = 4.8 (OECD Guideline 117 (Partition Coefficient ((n-octanol / water); HPLC Method); EU Method A.8 (Partition Coefficient))
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.8
- at the temperature of:
- 20 °C
Additional information
The test item can be considered as not ionisable because the water solubility showed no pH dependency. Thus a pH dependence of the Pow of substance test was not expected and the partition coefficient was determined only at pH 6.5.
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