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EC number: 246-904-0 | CAS number: 25371-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 July 2012 to 26 February 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Reference substance name:
- M-5925
- IUPAC Name:
- M-5925
- Test material form:
- other: waxy solid
- Details on test material:
- Identification: Dimethyl octadecylphosphonate (CAS No. 25371-54-4)
Batch: B12-5990
Purity: >98% dimethyl octadecylphosphonate
Description: White waxy solid
Storage conditions: room temperature, in the dark
Expiry Date: 18 July 2013
Constituent 1
Constituent 2
- Radiolabelling:
- no
Study design
HPLC method
- Details on study design: HPLC method:
- The determination was carried out using the HPLC screening method, designed to be compatible with OECD 121. The test utilised a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The dead time was determined by measuring the retention time of thiourea at 600 mg/L solution in methanol:water (55:45, v/v). Solutions of reference standards recommended for the determination of the adsorption coefficient by HPLC based on soil adsorption data (acetanilide, phenol, atrazine, isoproturon, linuron, naphthalene, endosulfan-diol, fenthion, α-edosulfan, phenanthrene and DDT) at approximately 100 mg/l were prepared in methanol. The test item, dimethyl octadecylphosphonate (DMOP) was diluted in tetrahydrofuran to give a concentration of approximately 5 g/l.
The DMOP sample, dead time and reference standard solutions were injected in duplicate using the HPLC system and parameters detailed in the section below.
A calibration curve was constructed from the retention time data of the dead time and reference standard solutions.
The capacity factor and the log10Koc value were determined using the equations below:
Capacity Factor
The capacity factor was determined using the equation below:
k' = (tr - t0)/ t0
Where:
k' = capacity factor
tr = retention time (min)
t0= dead time (min)
Adsorption Coefficient
Log10Koc = (Log10 k' – A)/B
Where
Koc = adsorption coefficient
k' = capacity factor
A = intercept of the calibration curve
B = slope of the calibration curve
The capacity factors k' for the reference standards were calculated using the equation above.
Batch equilibrium or other method
- Analytical monitoring:
- not required
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Value:
- > 5.63
- Type:
- Koc
- Value:
- > 427 000
Results: HPLC method
- Details on results (HPLC method):
- The retention time of the dead time was 1.948 min.
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- The adsorption coefficient of the DMOP was been determined to be >427000, log10 Koc >5.63.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item has been determined to be >427000, log10 Koc >5.63.
- Executive summary:
The adsorption coefficinet was determined using the HPLC screening method designed to be compatible with OECD Guideline 121. The test utilised a high performance liquid chromatograph and a commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties. The dead time was determined by measuring the retention time of thiourea. Solutions of reference standards recommended for the determination of the adsorption coefficient based on soil adsorption data were analysed. The dimethyl octadecylphosphonate (DMOP) sample, dead time and reference standard solutions were injected in duplicate and a calibration curve was constructed from the retention time data of the dead time and reference standard solutions.
As the slope of the calibration curve for the reference standards showed good first order correlation and as the retention times between duplicate injections for each solution was consistent, the HPLC method was considered valid for the determination of adsorption coefficient.
The adsorption coefficient of the DMOP was determined to be >427000, log10 Koc >5.63.
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