Registration Dossier
Registration Dossier
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EC number: 701-017-2 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Full GLP report guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM method E981-84, Standard Method for Estimating Sensory Irritation of Airborne Chemicals, 1984
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- m-tolylidene diisocyanate
- EC Number:
- 247-722-4
- EC Name:
- m-tolylidene diisocyanate
- Cas Number:
- 26471-62-5
- IUPAC Name:
- 2,4-diisocyanato-1-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Mondur TD 80
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- The test substance was generated as a vapor in a glass bubbler, immersed in a water bath at 25 degree C, and concentrations achieved by varying the rate of airflow.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Concentrations of Mondur TD-80 in the exposure chamber were determined at 0.5, 1.5, and 2.5 hours of exposure.
- Duration of treatment / exposure:
- 3h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.10 to 1.45 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 4
- Details on study design:
- Statistics
The RD 50 value with 95% confidence limits were calculated by probit analysis using computer programs of SAS (SAS Institute Inc. Cary, North Carolina, US)
Results and discussion
- Details on results:
- Effect levels
Sex male
Endpoint other: RD50
Effect level 2.12 ppm
95% CL 1.61 — 3.4
Exp. duration 3 h
Remarks
Any other information on results incl. tables
Remarks on results including tables and figures
95% confidence interval = 1.61 - 3.40 ppm
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Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
