Registration Dossier
Registration Dossier
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EC number: 939-071-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
In the dermal in vivo study, severe erythema (score of 4) and very slight to slight edema (scores of 1 or 2) were noted at the 3-minute, 1-hour and 4-hour treated dose sites. Brown discoloration and blanching were evident at the 1- and 4- hour sites. The area outside of the 4-hour dose site also appeared to have destruction of the top skin layer. Based on this study in one animal, the test material was considered to be corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the dermal in vivo study, severe erythema (score of 4) and very slight to slight edema (scores of 1 or 2) were noted at the 3-minute, 1-hour and 4-hour treated dose sites. Brown discoloration and blanching were evident at the 1- and 4- hour sites. The area outside of the 4-hour dose site also appeared to have destruction of the top skin layer. Based on this study in one animal, the test material was considered to be corrosive.
Justification for selection of skin irritation / corrosion endpoint:
In an in vivo study, paraformaldehyde, oligomeric reaction products with 4-tert-butylphenol, m-phenylenebis(methylamine) (Mannich Base PTBP-MXDA) caused corrosion at the 4-hour exposure site for the 30-60 minute scoring interval.
Justification for selection of eye irritation endpoint:
Due to skin corrosivity result, eye irritation study was not conducted.
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
