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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets basic scientific principles; comparable to guideline study; basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
; 10 animals per dose level, no pathology, only one sex tested, limited reporting
GLP compliance:
no
Remarks:
pre-GLP stuidy
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(1-methylethyl)-1,1'-biphenyl
EC Number:
247-156-8
EC Name:
(1-methylethyl)-1,1'-biphenyl
Cas Number:
25640-78-2
Molecular formula:
C15H16
IUPAC Name:
(1-methylethyl)-1,1'-biphenyl
Details on test material:
- Name of test material (as cited in study report): Sun oil X489-17B
- no further information

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Fasting period before study: 24 h
- Animals were fed, housed and watered in accordance with standard laboratory procedures.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
1, 3, 5, 8, 10, and 15 g/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations at 1, 3, 6, 24, 48, 72 h, and daily thereafter; no information on weighing
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Statistics:
LD 50 was determined in accordance with the method of Miller and Tainter (Proc. Soc. Exp. Biol. Med. NY , 57, 261-264, 1944)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 650 mg/kg bw
Based on:
test mat.
Remarks on result:
other: S.E. = 640 mg/kg bw
Clinical signs:
other: Decreased locomotor activity, piloerection, ataxia, ptosis. In the lowest dose group, slight systemic toxicity prevalently related to CNS effects (decreased locomotor activity) was observed. 4 days after treatment, the test animals appeared normal again.
Gross pathology:
no data
Other findings:
--

Any other information on results incl. tables

Mortality

 

Dose
[g/kg bw]

Animals per Group

Day

Total

2

3

4

1

10

0

0

0

0/10

3

10

0

1

1

2/10

5

10

0

4

2

6/10

8

10

2

5

1

8/10

10

10

3

3

2

8/10

15

10

0

3

7

10/10

 

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Monoisopropylbiphenyl is only slightly acute toxic. LD50 was determined to be 4650 mg/kg bw. Classification according EU regulations is not required.