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New Data Availability System
A new Data Availability System is being developed by ECHA. To begin with this system will take over the responsibility of making REACH registration data available, once it is ready. We expect the first version to be publicly available by the end of January 2024.
Since ECHA aims to devote our maximum effort to this new system, we can no longer maintain REACH registration data on the current Dissemination Platform. As such once the IUCLID format change begins on 19th May 2023 we will no longer update REACH registered substance factsheets. The factsheets will remain online, but will not be updated.
New and updated REACH registration submissions, as well as all registrations on file, will be made available in the new system when it is ready. We will inform you of what you can expect in the new System, along with details of when and where to find it.
We appreciate your understanding in the meantime.
DISSEMINATION
PLATFORM
REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation
Registered Substances Factsheets
Substances which have been registered and can be placed on the EEA market by those companies with a valid registration
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Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
---|---|---|---|---|---|---|---|---|
Sun Chemical B.V. | Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands | Netherlands | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | - | View substance registered dossier |
ICL Europe Coöperatief U.A. (OR1) | Koningin Wilhelminaplein 30 Prinsenhof 1062 KR Amsterdam Netherlands | Netherlands | Cease Manufacture | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | 2017 | View substance registered dossier |
NAM & NAM Europe GmbH | Am Kronberger Hang 2 65824 Schwalbach Germany | Germany | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | - | View substance registered dossier |
TÜV SÜD Iberia S.A.U. (051) | Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain | Spain | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | - | View substance registered dossier |
KTR Europe GmbH | Mergenthalerallee 77 65760 Eschborn Germany | Germany | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | - | View substance registered dossier |
Spolek pro chemickou a hutní výrobu, a.s. | Revoluční 1930/86 400 32 Ústí nad Labem Czech Republic | Czech Republic | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | - | View substance registered dossier |
TÜV SÜD Industrie Service GmbH (45) | Westendstrasse 199 80686 Munich Germany | Germany | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | - | View substance registered dossier |
Blue Cube Netherlands B.V. | Axelsedam 3a 4531HH Terneuzen Netherlands | Netherlands | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | - | View substance registered dossier |
Blue Cube Chemicals Italy S.r.l. | Corso Giuseppe Garibaldi 86 20121 Milano Italy | Italy | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 | 2014; 2017; 2018; 2019; 2021; 2022; 2023 | View substance registered dossier |
KTR Europe GmbH | Mergenthalerallee 77 65760 Eschborn Germany | Germany | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane and 2,4,6-tribromophenol | 500-399-6 | 158725-44-1 | - | View substance registered dossier |
ICL Europe Coöperatief U.A. (OR1) | Koningin Wilhelminaplein 30 Prinsenhof 1062 KR Amsterdam Netherlands | Netherlands | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane and 2,4,6-tribromophenol | 500-399-6 | 158725-44-1 | 2017 | View substance registered dossier |
Plixxent B.V. | Korte Groningerweg 1A 9607 Foxhol Netherlands | Netherlands | Active | 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with Propylene oxide and n-butyl glycidyl ether | 926-564-6 | - | 2016; 2018; 2019; 2021; 2022; 2023 | View substance registered dossier |
Aceto France S.A.S | 3 Rue de Genève CS 50363 69451 Lyon Cedex 06 Cedex 06 France | France | Active | 2,2'-(1,3-phenylene)bis(4,5-dihydro-1,3-oxazole) | 421-510-3 | 34052-90-9 | - | View substance registered dossier |
Nexam Performance Masterbatch AB | Industrigatan 27 234 35 Lomma Sweden | Sweden | Active | 2,2'-(1,3-phenylene)bis(4,5-dihydro-1,3-oxazole) | 421-510-3 | 34052-90-9 | - | View substance registered dossier |
Thomas Swan & Co. Ltd. | Rotary Way DH8 7ND Consett Co. Durham United Kingdom | United Kingdom | No longer Valid | 2,2'-(1,3-phenylene)bis(4,5-dihydro-1,3-oxazole) | 421-510-3 | 34052-90-9 | 2021 | View substance registered dossier |
[Confidential] | - | - | - | 2,2'-(1,3-phenylene)bis(4,5-dihydro-1,3-oxazole) | 421-510-3 | 34052-90-9 | - | View substance registered dossier |
Nexam Chemical AB | Industrigatan 27 SE23435 Lomma Sweden | Sweden | Active | 2,2'-(1,3-phenylene)bis(4,5-dihydro-1,3-oxazole) | 421-510-3 | 34052-90-9 | 2020 | View substance registered dossier |
Nexam St Andrews Ltd | Prestonhall Industrial Estate KY15 4RD Cupar Fife United Kingdom | United Kingdom | No longer Valid | 2,2'-(1,3-phenylene)bis(4,5-dihydro-1,3-oxazole) | 421-510-3 | 34052-90-9 | 2021 | View substance registered dossier |
Heubach Colorants Germany GmbH | Brüningstrasse 50 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(1,4-phenylene)bis[4-[(4-methoxyphenyl)methylene]oxazol-5(4H)-one] | 257-055-0 | 51202-86-9 | 2016 | View substance registered dossier |
Texco Farben Produktionsgesellschaft mbH | Salegaster Chaussee 06803 Greppin Germany | Germany | Active | 2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione) | 255-078-0 | 40783-05-9 | - | View substance registered dossier |
DyStar Colours Distribution GmbH | Am Prime-Parc 12 65479 Raunheim Germany | Germany | Active | 2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione) | 255-078-0 | 40783-05-9 | - | View substance registered dossier |
SI Group Germany (DEAB) GmbH | Teplitzer Strasse 14-16 84478 Waldkraiburg Germany | Germany | Active | 2,2'-(2-methylpropylidene)bis[4,6-xylenol] | 251-394-8 | 33145-10-7 | - | View substance registered dossier |
Clariant Produkte (Deutschland) GmbH | August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(C12-14 evennumbered alkyl imino) diethanol | 946-745-3 | - | 2018; 2021; 2022 | View substance registered dossier |
ARKEMA FRANCE | 420 rue d'Estienne d'Orves 92700 COLOMBES France | France | Active | 2,2'-(C16-18 (evennumbered) alkyl imino) diethanol | 620-539-0 | 1218787-30-4 | 2021 | View substance registered dossier |
Arkema Antwerpen | Avenue Louise 149/24 B-1050 Bruxelles Belgium Belgium | Belgium | Active | 2,2'-(C16-18 (evennumbered) alkyl imino) diethanol | 620-539-0 | 1218787-30-4 | 2021 | View substance registered dossier |
Nouryon Functional Chemicals B.V. | Haaksbergweg 88 1101 BZ Amsterdam The Netherlands Netherlands | Netherlands | Active | 2,2'-(C16-18 (evennumbered) alkyl imino) diethanol | 620-539-0 | 1218787-30-4 | 2019 | View substance registered dossier |
Clariant Produkte (Deutschland) GmbH | August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(C16-18 (evennumbered) alkyl imino) diethanol | 620-539-0 | 1218787-30-4 | - | View substance registered dossier |
Nouryon Surface Chemistry AB | Box 47067 40258 Göteborg Sweden | Sweden | Active | 2,2'-(C16-18 (evennumbered) alkyl imino) diethanol | 620-539-0 | 1218787-30-4 | 2014; 2021; 2023 | View substance registered dossier |
Clariant SE - CN15 | August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(C16-18 (evennumbered) alkyl imino) diethanol | 620-539-0 | 1218787-30-4 | 2023 | View substance registered dossier |
SABO SPA | Via Caravaggi 24040 Levate Bergamo Italy | Italy | Active | 2,2'-(C16-18 (evennumbered) alkyl imino) diethanol | 620-539-0 | 1218787-30-4 | - | View substance registered dossier |
Lubrizol France SAS | 25 Quai de France 76100 ROUEN France | France | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | - | View substance registered dossier |
SABO SPA | Via Caravaggi 24040 Levate Bergamo Italy | Italy | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | - | View substance registered dossier |
Nouryon Functional Chemicals B.V. | Haaksbergweg 88 1101 BZ Amsterdam The Netherlands Netherlands | Netherlands | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2019 | View substance registered dossier |
RHODIA OPERATIONS - 44 | 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 LYON France | France | Cease Manufacture | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2022 | View substance registered dossier |
BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | - | View substance registered dossier |
Lamberti S.p.A. | via Piave 18 21041 Albizzate Varese Italy | Italy | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | - | View substance registered dossier |
ARKEMA FRANCE | 420 rue d'Estienne d'Orves 92700 COLOMBES France | France | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2021 | View substance registered dossier |
Lubrizol Europe Coordination Center BVBA 05 | Chaussee De Wavre 1945 Brussels Belgium | Belgium | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2019 | View substance registered dossier |
Nouryon Surface Chemistry AB | Box 47067 40258 Göteborg Sweden | Sweden | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2012; 2013; 2014; 2015; 2018; 2021 | View substance registered dossier |
BASF Italia S.p.A. | Via Marconato 8 20811 Cesano Maderno Italy | Italy | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | - | View substance registered dossier |
Lubrizol Europe Coordination Center BVBA 01 | Chaussee De Wavre, 1945 1945 Brussels Belgium | Belgium | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2019 | View substance registered dossier |
Clariant SE - IN20 | August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | - | View substance registered dossier |
Nouryon Surface Chemistry AB | Box 47067 40258 Göteborg Sweden | Sweden | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2014; 2021 | View substance registered dossier |
Lubrizol Europe Coordination Center BVBA 16 | Chaussee De Wavre 1945 Brussels Belgium | Belgium | Active | 2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | 2019 | View substance registered dossier |
Yordas GmbH | Äußere Nürnberger Str. 62, 91301 Forchheim Germany | Germany | Active | 2,2'-(cyclohexylimino)bisethanol | 224-809-5 | 4500-29-2 | - | View substance registered dossier |
Clariant Ibérica Producción S.A. | Avda. Baix Llobregat, 3-5 08970 Sant Joan Despí Barcelona Spain | Spain | Active | 2,2'-(cyclohexylimino)bisethanol | 224-809-5 | 4500-29-2 | 2021 | View substance registered dossier |
Clariant Produkte (Deutschland) GmbH | August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(cyclohexylimino)bisethanol | 224-809-5 | 4500-29-2 | 2019; 2021 | View substance registered dossier |
John Dunleavt T/A Waltham Advisory | 45 Waltham Terrace Blackrock A94 K5F7 Dublin Ireland | Ireland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2020 | View substance registered dossier |
Eastman Specialties AS | Uus Tehas 8 30328 Kohtla-Jarve Estonia | Estonia | Cease Manufacture | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016 | View substance registered dossier |
ITW Performance Polymers, A Division of ITW Ireland | Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland | Ireland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
Helm AG | Nordkanalstraße 28 20097 Hamburg Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2011; 2012; 2016 | View substance registered dossier |
Sasol Germany GmbH | Anckelmannsplatz 1 D-20537 Hamburg Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2011; 2012; 2016; 2020 | View substance registered dossier |
Shell Chemicals Europe B.V. | Weena 505 3013 AL Rotterdam Netherlands Netherlands | Netherlands | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016; 2020 | View substance registered dossier |
INDUSTRIAS QUIMICAS DEL OXIDO DE ETILENO, S.A. | AVDA. REMOLAR, 2 08820 PRAT DE LLOBREGAT Spain | Spain | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2011; 2012; 2014; 2016 | View substance registered dossier |
Dow Belgium B.V.B.A. | Grotesteenweg 214 B-2600 Antwerpen (Berchem) Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016 | View substance registered dossier |
HUNTSMAN HOLLAND BV | Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands | Netherlands | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2023 | View substance registered dossier |
[Confidential] | - | - | - | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
Ramboll Belgium bvba | Meersbloem-Melden 46 9700 Oudenaarde Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
REACHLINKED OÜ | Ahtri tn 12 10151 Tallinn Estonia | Estonia | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
BASF Antwerpen N.V. | Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2011; 2012; 2015; 2019; 2020; 2023 | View substance registered dossier |
TÜV SÜD Iberia S.A.U. (049) | Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain | Spain | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2020 | View substance registered dossier |
REACHLaw Ltd | Aleksanterinkatu 19 00100 Helsinki Finland | Finland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2020 | View substance registered dossier |
Shell Nederland Chemie B.V. | Chemieweg 25 PO BOX 6060, 4782 SJ Moerdijk Netherlands | Netherlands | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016; 2020 | View substance registered dossier |
Memjet Limited | Trintech Building South County Business Park, Leopards Town D18 H5H9 Dublin Ireland | Ireland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
ExponentOR30IRE | Block 1, Blanchardstown Corporate Park D15 AKK1 Dublin Ireland | Ireland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2021 | View substance registered dossier |
BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2011; 2012; 2015; 2020 | View substance registered dossier |
TÜV SÜD Iberia, S.A.U. (083) | Ronda Can Fatjó, 13 08290 Cerdanyola del Vallès (Barcelona) Spain | Spain | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
REACH NATION 2 | Avenue du Pesage 18, Box 9 1050 Brussels Belgium | Belgium | Cease Manufacture | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2014 | View substance registered dossier |
Labcorp Development SA 104 | Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain | Spain | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016; 2021 | View substance registered dossier |
OQ Chemicals GmbH | Rheinpromenade 4a 40789 Monheim NRW Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2012 | View substance registered dossier |
Liquichem Handelsgesellschaft mbH | Kajen 6–8 20459 Hamburg Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2012; 2016 | View substance registered dossier |
Mitsubishi_Chemical_Europe_GmbH | Schiessstraße 47 40549 Düsseldorf Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2017; 2021; 2022; 2023 | View substance registered dossier |
BD&I_37 | rue Omer Lepreux, 92 1081 bruxelles Belgium Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016 | View substance registered dossier |
Petrochemical Commercial Company (UK) Ltd | 24, GROSVENOR GARDENS SW1W 0DH LONDON EUROPE United Kingdom | United Kingdom | No longer Valid | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2021 | View substance registered dossier |
DOW BENELUX B.V. | Postbus 48 4530 AA Terneuzen Netherlands | Netherlands | Cease Manufacture | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2023 | View substance registered dossier |
Labcorp Development SA 024 | Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain | Spain | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2023 | View substance registered dossier |
Oxiteno Europe OR2 | Ikaroslaan 6 1930 Zaventem Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2020 | View substance registered dossier |
ExxonMobil Petroleum & Chemical BV | Polderdijkweg 2030 Antwerpen Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2019; 2020 | View substance registered dossier |
BCI POLYURETHANE EUROPE SRL | P.le Cocchi 22 (Z.I) 21040 Vedano Olona (VA) Italy | Italy | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
Cambridge Environmental Assessments, part of RSK ADAS Europe (Ireland) Ltd (MIK) | Office Suite B, Bluebell Business Centre Old Naas Road DB12XV7K Dublin Ireland | Ireland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016; 2019; 2020 | View substance registered dossier |
TÜV SÜD Iberia S.A.U. (051) | Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain | Spain | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2020 | View substance registered dossier |
Kodak GmbH | Kesselstrasse 19 70327 Stuttgart Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
ERM_GmbH_OR13_KM | Siemenstrasse 9. 63263 Neu Isenburg Hessen Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
Huntsman (Europe) BV - OR5 | Everslaan 45 B-3078 Everberg Belgium | Belgium | Cease Manufacture | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2022 | View substance registered dossier |
ChampionX Europe B.V. | Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands | Netherlands | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
BD&I_15 | 92 rue Omer Lepreux 1081 Koekelberg Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
HVL GmbH | Ernst-Eisenlohr-Str. 14 79410 Badenweiler Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
B-Lands Consulting (8111117-5) | World Trade Center, 5 Place Robert Schuman - BP1510 38025 Grenoble France France | France | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016; 2019; 2020 | View substance registered dossier |
Clariant Produkte (Deutschland) GmbH | August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2011; 2016; 2021 | View substance registered dossier |
INEOS nv | Haven 1053 -- Nieuwe Weg 1 2070 Zwijndrecht Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2013; 2014; 2016; 2020 | View substance registered dossier |
HML Europe BV | De Haal 82 1511 AT Oostzaan Netherlands | Netherlands | No longer Valid | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2016 | View substance registered dossier |
INEOS Manufacturing Deutschland GmbH | Alte Strasse 201 50769 Koeln Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2013; 2014; 2016; 2020 | View substance registered dossier |
Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden | Sweden | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
Polski Koncern Naftowy ORLEN SA | ul. Chemików 7 09-411 Płock Poland Poland | Poland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2011; 2012; 2013; 2014; 2016; 2020; 2023 | View substance registered dossier |
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(Speed Infotech (Beihai) Company Limited) | Regus Harcourt Centre D02 HW77 Dublin Ireland | Ireland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
SABIC Petrochemicals B.V. | Europaboulevard 1 6135 LD Sittard Limburg Netherlands | Netherlands | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2010; 2013 | View substance registered dossier |
Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | Sweden | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
Yordas GmbH | Äußere Nürnberger Str. 62, 91301 Forchheim Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2019 | View substance registered dossier |
ANTWERP DISTILLATION COMPANY NV | GESLECHT PORT 1931 B-9130 KALLO Belgium | Belgium | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | - | View substance registered dossier |
STEPAN POLSKA | Urazka Street PL 56-120 Brzeg Dolny Poland | Poland | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2020 | View substance registered dossier |
Merck Schuchardt OHG | Eduard-Buchner-Str. 85662 Hohenbrunn Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2021 | View substance registered dossier |
Fujifilm Europe GmbH (OR3) | Balcke-Dürr-Allee 6 40882 Ratingen NRW Germany | Germany | Active | 2,2'-(ethylenedioxy)diethanol | 203-953-2 | 112-27-6 | 2023 | View substance registered dossier |
[Confidential] | - | - | - | 2,2'-(m-tolylimino)diethanol | 202-114-8 | 91-99-6 | - | View substance registered dossier |
Saltigo GmbH | HSEQ-RA Kaiser-Wilhelm-Allee 40 51373 Leverkusen Germany | Germany | Active | 2,2'-(m-tolylimino)diethanol | 202-114-8 | 91-99-6 | - | View substance registered dossier |
WELWIN CHEMICALS EUROPE LIMITED | JAMES F. WALLACE & CO. 14 GLADSTONE STREET X91 YNH1 WATERFORD Ireland | Ireland | Active | 2,2'-(m-tolylimino)diethanol | 202-114-8 | 91-99-6 | 2021 | View substance registered dossier |
CS Regulatory IRL Ltd 1L-6 | Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland | Ireland | Active | 2,2'-(methylenebis((2,6-dimethyl-4,1-phenylene)oxymethylene))bis oxirane | 439-910-1 | 93705-66-9 | - | View substance registered dossier |
ExponentOR35I | Block 1, Blanchardstown Corporate Park Ballycoolin Road, Blanchardstown D15 AKK1 Dublin Ireland | Ireland | Cease Manufacture | 2,2'-(methylenebis((2,6-dimethyl-4,1-phenylene)oxymethylene))bis oxirane | 439-910-1 | 93705-66-9 | 2022 | View substance registered dossier |
Archroma Germany GmbH | Kasteler Str. 45 65203 Wiesbaden Germany | Germany | Active | 2,2'-(naphthalene-1,4-diyl)bis(benzoxazole) | 225-803-5 | 5089-22-5 | 2021 | View substance registered dossier |
SABO SPA | Via Caravaggi 24040 Levate Bergamo Italy | Italy | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | 2021 | View substance registered dossier |
Cytec Industries BV | Weena 505 3013 AL Rotterdam Netherlands | Netherlands | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | 2019 | View substance registered dossier |
Clariant SE - IN20 | August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | - | View substance registered dossier |
RHODIA OPERATIONS | 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 LYON France | France | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | - | View substance registered dossier |
Innospec Performance Chemicals France SAS | Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France | France | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | - | View substance registered dossier |
BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | - | View substance registered dossier |
Nouryon Surface Chemistry AB | Box 47067 40258 Göteborg Sweden | Sweden | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | 2011; 2012; 2013; 2014; 2015; 2019; 2020; 2021; 2022 | View substance registered dossier |
Solvay Solutions Italia S.p.A. | Via Milano, 78/80 20021 Ospiate di Bollate (Mi) Italy | Italy | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | 2020; 2022 | View substance registered dossier |
BASF Italia S.p.A. | Via Marconato 8 20811 Cesano Maderno Italy | Italy | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | - | View substance registered dossier |
Arkema Antwerpen | Avenue Louise 149/24 B-1050 Bruxelles Belgium Belgium | Belgium | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | 2021 | View substance registered dossier |
Clariant Produkte (Deutschland) GmbH | August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | 2015; 2022 | View substance registered dossier |
ARKEMA FRANCE | 420 rue d'Estienne d'Orves 92700 COLOMBES France | France | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | 2013; 2021 | View substance registered dossier |
Lamberti S.p.A. | via Piave 18 21041 Albizzate Varese Italy | Italy | Active | 2,2'-(octadec-9-enylimino)bisethanol | 246-807-3 | 25307-17-9 | - | View substance registered dossier |
Nouryon Surface Chemistry AB | Box 47067 40258 Göteborg Sweden | Sweden | Active | 2,2'-(octadecylimino)bisethanol | 233-520-3 | 10213-78-2 | 2016; 2019; 2021; 2023 | View substance registered dossier |
SABO SPA | Via Caravaggi 24040 Levate Bergamo Italy | Italy | Active | 2,2'-(octadecylimino)bisethanol | 233-520-3 | 10213-78-2 | 2021 | View substance registered dossier |
KTR Europe GmbH | Mergenthalerallee 77 65760 Eschborn Germany | Germany | Active | 2,2'-(octadecylimino)bisethanol | 233-520-3 | 10213-78-2 | 2021 | View substance registered dossier |
INTERTEK FRANCE | ZAC Ecoparc II 27400 HEUDEBOUVILLE France | France | Active | 2,2'-(octadecylimino)bisethanol | 233-520-3 | 10213-78-2 | - | View substance registered dossier |
ARKEMA FRANCE | 420 rue d'Estienne d'Orves 92700 COLOMBES France | France | Active | 2,2'-(octadecylimino)bisethanol | 233-520-3 | 10213-78-2 | 2022 | View substance registered dossier |
Clariant Produkte (Deutschland) GmbH | August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany | Germany | Active | 2,2'-(octylimino)bisethanol | 239-555-0 | 15520-05-5 | 2017; 2018; 2021 | View substance registered dossier |
Clariant Ibérica Producción S.A. | Avda. Baix Llobregat, 3-5 08970 Sant Joan Despí Barcelona Spain | Spain | Active | 2,2'-(octylimino)bisethanol | 239-555-0 | 15520-05-5 | 2019; 2021; 2022 | View substance registered dossier |
BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Active | 2,2'-(octylimino)bisethanol | 239-555-0 | 15520-05-5 | 2021 | View substance registered dossier |
REACH&Colours Kft | Petofi Sandor utca 11 I Em. 4 1052 Budapest Hungary | Hungary | Active | 2,2'-(p-phenylenediethene-2,1-diyl)bisbenzonitrile | 235-835-1 | 13001-39-3 | 2018; 2022 | View substance registered dossier |
DyStar Colours Distribution GmbH | Am Prime-Parc 12 65479 Raunheim Germany | Germany | Active | 2,2'-(p-phenylenediethene-2,1-diyl)bisbenzonitrile | 235-835-1 | 13001-39-3 | 2022 | View substance registered dossier |
Reach & Colours Trade Kft | Levente u. 14/a 2161 Csomád Hungary | Hungary | Active | 2,2'-(p-phenylenediethene-2,1-diyl)bisbenzonitrile | 235-835-1 | 13001-39-3 | - | View substance registered dossier |
Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden | Sweden | Active | 2,2'-(p-phenylenediethene-2,1-diyl)bisbenzonitrile | 235-835-1 | 13001-39-3 | 2018 | View substance registered dossier |
Archroma Germany GmbH | Kasteler Str. 45 65203 Wiesbaden Germany | Germany | Active | 2,2'-(p-phenylenediethene-2,1-diyl)bisbenzonitrile | 235-835-1 | 13001-39-3 | 2022 | View substance registered dossier |
ARCHROMA IBÉRICA, S.L. | ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain | Spain | Cease Manufacture | 2,2'-(p-phenylenediethene-2,1-diyl)bisbenzonitrile | 235-835-1 | 13001-39-3 | 2022 | View substance registered dossier |
REACH24H CONSULTING GROUP | Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland | Ireland | Active | 2,2'-(p-phenylenediethene-2,1-diyl)bisbenzonitrile | 235-835-1 | 13001-39-3 | - | View substance registered dossier |
SIGMA-ALDRICH CHEMIE GMBH | Riedstrasse 2 89555 Steinheim Germany | Germany | Active | 2,2'-(piperazine-1,4-diyl)bis(ethanesulphonic) acid | 227-057-6 | 5625-37-6 | 2021 | View substance registered dossier |
Sigma-Aldrich Company Limited | The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom | United Kingdom | No longer Valid | 2,2'-(piperazine-1,4-diyl)bis(ethanesulphonic) acid | 227-057-6 | 5625-37-6 | 2021 | View substance registered dossier |
Roche Diagnostics GmbH | Sandhoferstrasse 116 68305 Mannheim Germany | Germany | Active | 2,2'-(piperazine-1,4-diyl)bis(ethanesulphonic) acid | 227-057-6 | 5625-37-6 | 2022 | View substance registered dossier |
TÜV SÜD Iberia S.A.U. | Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain | Spain | Active | 2,2'-(piperazine-1,4-diyl)bis(ethanesulphonic) acid | 227-057-6 | 5625-37-6 | - | View substance registered dossier |
Sigma-Aldrich Ireland Ltd | Vale Road . Arklow Co. Wicklow Ireland | Ireland | Active | 2,2'-(piperazine-1,4-diyl)bis(ethanesulphonic) acid | 227-057-6 | 5625-37-6 | - | View substance registered dossier |
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.
RELATED INFORMATION
- Registered substances information
- How to determine what will be published (Data Submission Manual 15)
- Understanding REACH Regulation
- Q&A on registered substances
- What is an Infocard? [PDF]
- What is a Registered substance Factsheet? [PDF]
- eChemPortal
- REACH study results download
- REACH Regulation
- ECHA Legal notice
Welcome to the REACH Registered Substance Factsheets
Here you will find details from REACH registrations submitted to ECHA. Registrations under REACH can be submitted either jointly – where a group of legal entities pool their data – or individually. The set of details from each published joint or individual submission is presented as a row in the results table. For each row there is also an ‘eye’ icon leading to the detailed factsheet which contains the entire public dataset, following the IUCLID format.
Note that there can be more than one joint or individual submission for the same substance, thus there can be cases where one substance is covered by many REACH registered substance factsheets.
Note too, that as mentioned in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission.
Finally, please note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
All substances table
The “All substances” table gives an overview of all the REACH registered substance factsheets on file at ECHA. Since this covers all data ever submitted since the entry into force of the REACH Regulation, there are some substances which are no longer considered registered under REACH in the EU / EEA. These can be for example substances that were registered only in the UK; since Brexit they are no longer registered in the EU / EEA.
The following columns are presented in the “All substances” table:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- ‘Eye’ icon linking to the full factsheet.
Searching
The search for REACH registered substance factsheets is divided into logically separated blocks of related search filters. Note that the search works so that if you provide filters in different blocks, then the results returned must match the filters in block 1 AND those in block 2 etc. Searches are conducted on all the public data included in all published REACH registrations.
Substance identity
In this block you can search by substance identifiers, under filters for Name, EC / List number, and CAS number. Full or partial identifiers can be used. And under the Name filter you can search by any substance name of any kind from any source. Other numerical identifiers such as Harmonised C&L Index number, or PIC CN code can also optionally be used.
Administrative data
In this block you can search by administrative information relating to REACH registered substance factsheets:
- Registration type – picklist of Full, Intermediate, NONS
- Registration status – picklist of Active, Cease Manufacture, No longer valid
- Submission type – Individual or Joint
- Country in which registered – picklist of current and former EU / EEA member states from which REACH registrations were received
- First published date – the date when a REACH registration factsheet was first published
- Last update date – the last date when any registrant / supplier submission contributing to a given REACH registration factsheet was submitted
- Last update year – the year in which any registrant / supplier last made an update submission included in a given REACH registration factsheet
- Registrant / supplier name – where available and not claimed confidential
- Registration number – where available and not claimed confidential
- Registrant address – where available and not claimed confidential
Substance data
In this block you can search by substance related data from REACH registered substance factsheets:
- Tonnage band – picklist of Tonnage range, Tonnage Confidential, Intermediate use only
- Selected total tonnage band range – available only if Tonnage range is selected, and allows to filter REACH registered substance factsheets within any selected min and max value
- Substance has nanoform – picklist of Yes, No
- PBT assessment outcome – picklist of all possible PBT assessment outcomes
- CSA performed – picklist of Yes, No
Use and exposure
In this block you can search by elements relating to how use and exposure are encoded in REACH registrations.
Under the Life cycle option you can select one or more life cycle stages. The search results returned will include only factsheets containing uses reported under the selected life cycle stages.
Under the Category option there are modal popups for each of the use descriptor categories – Product, Sector of use, Process, Environmental release, and Article categories. In each of these are multi select picklists for all the related descriptor codes. The search results returned will include only factsheets containing uses which include the selected descriptor codes.
Note that the Life cycle and Category options work together, so that if a life cycle stage and Category options are both selected the search results will include factsheets containing specific uses in the selected life cycle stage, and where the use includes the selected descriptor codes.
With the search operator option you can select to refine how the search works. AND refines results and returns only those factsheets where ALL the search filter criteria are met. OR broadens the results and returns factsheets where ANY of the selected search filter criteria are met.
The factsheets
There is always a detailed factsheet per joint or individual submission, and it is generated based primarily on the IUCLID format.
The factsheet header begins with the identity of the substance in question, to which the factsheet is linked. The substance identity should always be aligned with that shown in the related substance Infocard. Note that since the Infocard refreshes daily, whereas the factsheet sometimes refreshes on a slower pace, sometimes the data may be out of alignment. In such cases it will always realign as quickly as possible.
The substance identification is enriched with the data provided in the relevant IUCLID section of the primary submitted dossier – either the joint submission lead, or the single individual submission.
In this section are also provided the type of substance, all other identifiers such as trade names, common names, other names etc, as well as all distinct submitted compositions for the substance.
Next is a page covering administrative type information from the data submitted, including:
Registration details, on the total tonnage band informed to ECHA, the registration type, first published and last updated dates, and whether a chemical safety assessment has been performed.
Registrant / supplier details, giving the identity and status of registrants / suppliers, except where the identity has been claimed confidential.
Registration numbers, giving again the identity and status of registration numbers, except where claimed confidential.
Contact persons responsible for the SDS, giving the non-confidential SDS contacts provided to ECHA.
The remainder of the factsheet faithfully follows the IUCLID structure, covering the C&L and PBT, Manufacture, use, and exposure, Physical and chemical properties, Environmental fate and pathways, Ecotoxicological information, Toxicological information, Analytical methods (if available), Guidance on safe use, Assessment reports, and Reference substances.