Registered substances

Data platform availability banner - registered substances

The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM.  More

Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.


 

DISSEMINATION
PLATFORM

REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation

Registered Substances Factsheets

Substances which have been registered and can be placed on the EEA market by those companies with a valid registration



No results were found
Details
(2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
682-862-3 78715-23-8 No longer Valid Intermediate Joint No longer valid 12-04-2018 View substance registered dossier
(2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
682-862-3 78715-23-8 No longer Valid Intermediate Individual No longer valid 11-01-2016 View substance registered dossier
(2S)-1,1,2-triphenylethane-1,2-diol
624-788-6 108998-83-0 Active Intermediate Joint Intermediate use only 14-06-2018 View substance registered dossier
(2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride
953-783-4 2171323-89-8 Active Intermediate Joint Intermediate use only 24-06-2022 View substance registered dossier
(2S)-1,1-diphenylpropane-1,2-diol
443-220-6 46755-94-6 Cease Manufacture NONS Individual Cease manufacture 26-01-2012 View substance registered dossier
(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
214-494-2 1135-66-6 Active Full Joint ≥ 1 to < 10 tonnes 16-01-2019 View substance registered dossier
(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
214-494-2 1135-66-6 Active Intermediate Joint Intermediate use only 07-01-2020 View substance registered dossier
(2S)-1-(2-aminoacetyl)-N-[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[2-oxo-2-[[(1S)-1-methyl-2-oxo-2-[(2S)-2-[(2S)-2-[(2S)-2-[[(1S)-2-amino-1-(tert-butoxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]ethyl]amino]ethyl]amino]ethyl]amino]ethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
955-960-1 2656383-23-0 Active Intermediate Individual Intermediate use only 16-09-2022 View substance registered dossier
(2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
807-388-8 207557-35-5 Active Intermediate Joint Intermediate use only 11-11-2022 View substance registered dossier
(2S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid
928-037-6 2752-38-7 Active Intermediate Joint Intermediate use only 26-01-2018 View substance registered dossier
(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid
617-556-0 84348-37-8 Active Intermediate Joint Intermediate use only 03-08-2022 View substance registered dossier
(2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid
832-934-7 869001-86-5 Active Intermediate Joint Intermediate use only 18-03-2022 View substance registered dossier
(2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid
813-635-0 103336-06-7 Active Intermediate Joint Intermediate use only 07-12-2018 View substance registered dossier
(2S)-1-amino-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-aminium chloride
954-882-5 2628280-48-6 Active Intermediate Joint Intermediate use only 16-03-2022 View substance registered dossier
(2S)-1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid;N-cyclohexylcyclohexanamine
618-453-3 90104-21-5 Active Intermediate Individual Intermediate use only 21-03-2017 View substance registered dossier
(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
608-945-6 340-90-9 Active Full Joint ≥ 10 to < 100 tonnes 21-02-2023 View substance registered dossier
(2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid
443-560-5 88784-33-2 Active NONS Joint Tonnage data confidential 10-11-2008 View substance registered dossier
(2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol
605-429-2 16614-60-1 No longer Valid Intermediate Individual No longer valid 11-01-2016 View substance registered dossier
(2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol
605-429-2 16614-60-1 Active Intermediate Joint Intermediate use only 26-03-2019 View substance registered dossier
(2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5)
610-316-6 467426-34-2 Active Intermediate Joint Intermediate use only 11-08-2017 View substance registered dossier
No results were found
Registrant/Supplier Address Country Registration Status Name EC / List no. CAS no. Last update year Details
Macfarlan Smith Limited Wheatfield Road EH11 2QA Edinburgh United Kingdom United Kingdom No longer Valid (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol 682-862-3 78715-23-8 2021 View substance registered dossier
Indivior UK Ltd Henry Boot Way HU4 7DY Hull United Kingdom United Kingdom No longer Valid (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol 682-862-3 78715-23-8 2021 View substance registered dossier
UNION QUIMICO FARMACÉUTICA S.A. Mallorca 262 08008 Barcelona Barcelona Spain Spain Active (2S)-1,1,2-triphenylethane-1,2-diol 624-788-6 108998-83-0 - View substance registered dossier
Corteva Agriscience Spain, S.L.U Valle de Tamón s/n 33469 Carreño (Asturias) Spain 33469 Carreño (Asturias) Spain Spain Active (2S)-1,1-bis(4-fluorophenyl)propan-2-yl L-alaninate hydrochloride 953-783-4 2171323-89-8 - View substance registered dossier
DSM Nutritional Products GmbH Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany Germany Cease Manufacture (2S)-1,1-diphenylpropane-1,2-diol 443-220-6 46755-94-6 2019 View substance registered dossier
EcoGreen Fine Chemicals B.V. Lichtenauerlaan 102-120 3062ME Rotterdam Netherlands Netherlands Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2018 View substance registered dossier
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden Sweden Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2019 View substance registered dossier
REACH24H CONSULTING GROUP Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland Ireland Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 - View substance registered dossier
Symrise AG Mühlenfeldstraße 1 37603 Holzminden Germany Germany Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 2020 View substance registered dossier
IFF Benicarlo, S.L. Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain Spain Active (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene 214-494-2 1135-66-6 - View substance registered dossier
[Confidential] - - - (2S)-1-(2-aminoacetyl)-N-[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[(1S)-1-(tert-butoxymethyl)-2-oxo-2-[[2-oxo-2-[[(1S)-1-methyl-2-oxo-2-[(2S)-2-[(2S)-2-[(2S)-2-[[(1S)-2-amino-1-(tert-butoxymethyl)-2-oxo-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]ethyl]amino]ethyl]amino]ethyl]amino]ethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid 955-960-1 2656383-23-0 - View substance registered dossier
JSC "Olainfarm" Rupnicu str. 5 LV-2114 Olaine Latvia Latvia Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 2019 View substance registered dossier
Krka, d. d., Novo mesto Smarjeska cesta 6 SI-8501 Novo mesto Slovenia Slovenia Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 - View substance registered dossier
MOEHS BCN, S.L. C/ Zenc, 12 08755 Castellbisbal Barcelona Spain Spain Active (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile 807-388-8 207557-35-5 - View substance registered dossier
ERREGIERRE SPA Via Francesco Baracca, 19 24060 SAN PAOLO D'ARGON BERGAMO Italy Italy Active (2S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid 928-037-6 2752-38-7 - View substance registered dossier
Evonik Operations GmbH Rellinghauser Straße 1-11 45128 Essen Germany Germany Active (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid 617-556-0 84348-37-8 2020; 2022 View substance registered dossier
Curia Italy S.r.l. VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy Italy Active (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid 617-556-0 84348-37-8 - View substance registered dossier
Corden Pharma Bergamo S.p.A. Via Bergamo, 121 IT-24047 Treviglio BG Italy Italy Active (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid 832-934-7 869001-86-5 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)-1-({[(benzyloxy)carbonyl]amino}acetyl)-2-methylpyrrolidine-2-carboxylic acid 832-934-7 869001-86-5 - View substance registered dossier
Arran Chemical Company Ltd Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland Ireland Active (2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid 813-635-0 103336-06-7 - View substance registered dossier
Patheon Austria GmbH & Co KG St. Peterstrasse 25 A-4020 Linz Austria Austria Active (2S)-1-[(tert-butyl)oxycarbonyl]-2-methylpyrrolidine-2-carboxylic acid 813-635-0 103336-06-7 - View substance registered dossier
[Confidential] - - - (2S)-1-amino-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-aminium chloride 954-882-5 2628280-48-6 - View substance registered dossier
[Confidential] - - - (2S)-1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid;N-cyclohexylcyclohexanamine 618-453-3 90104-21-5 - View substance registered dossier
Roche Diagnostics GmbH Sandhoferstrasse 116 68305 Mannheim Germany Germany Active (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID 608-945-6 340-90-9 2019; 2022 View substance registered dossier
SIGMA-ALDRICH CHEMIE GMBH Riedstrasse 2 89555 Steinheim Germany Germany Active (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID 608-945-6 340-90-9 - View substance registered dossier
ISOCHEM 32 rue Lavoisier 91710 VERT LE PETIT France France Active (2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid 443-560-5 88784-33-2 - View substance registered dossier
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. - - No longer Valid (2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid 443-560-5 88784-33-2 2022 View substance registered dossier
Indivior UK Ltd Henry Boot Way HU4 7DY Hull United Kingdom United Kingdom No longer Valid (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-429-2 16614-60-1 2021 View substance registered dossier
Siegfried PharmaChemikalien Minden GmbH Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany Germany Active (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-429-2 16614-60-1 2019 View substance registered dossier
Macfarlan Smith Limited Wheatfield Road EH11 2QA Edinburgh United Kingdom United Kingdom No longer Valid (2S)-2-(17-carbonitrile-3,6-dimethoxy-4,5α-epoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol 605-429-2 16614-60-1 2021 View substance registered dossier
Siegfried St. Vulbas SAS 530, allée de la Luye 01150 SAINT VULBAS France France Active (2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5) 610-316-6 467426-34-2 - View substance registered dossier
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy Italy Active (2S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1, 1-TRIFLUOROBUT-3-YN-2-OL METHANESULFONATE (1:1.5) 610-316-6 467426-34-2 2017 View substance registered dossier

In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).

ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.

As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).

In the portal results table are presented:

  • Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
  • Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
  • Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
  • Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
  • Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
  • Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
  • Link to the full factsheet.

A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.