Registered substances
Registered substances
New Data Availability System
A new Data Availability System is being developed by ECHA. To begin with this system will take over the responsibility of making REACH registration data available, once it is ready. We expect the first version to be publicly available by the end of 2023.
Since ECHA aims to devote our maximum effort to this new system, we can no longer maintain REACH registration data on the current Dissemination Platform. As such once the IUCLID format change begins on 19th May 2023 we will no longer update REACH registered substance factsheets. The factsheets will remain online, but will not be updated.
New and updated REACH registration submissions, as well as all registrations on file, will be made available in the new system when it is ready. We will inform you of what you can expect in the new system, along with details of when and where to find it.
We appreciate your understanding in the meantime.
DISSEMINATION
PLATFORM
REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation
Registered Substances Factsheets
Substances which have been registered and can be placed on the EEA market by those companies with a valid registration
| Details | ||||||||
|---|---|---|---|---|---|---|---|---|
|
Hydrocortisone 21-acetate
|
200-004-4 | 50-03-3 | Active | Intermediate | Joint | Intermediate use only | 12-12-2012 | View substance registered dossier |
|
Cortisone 21-acetate
|
200-006-5 | 50-04-4 | Active | Intermediate | Joint | Intermediate use only | 14-01-2022 | View substance registered dossier |
|
Phenobarbital
|
200-007-0 | 50-06-6 | Active | Intermediate | Joint | Intermediate use only | 23-03-2018 | View substance registered dossier |
|
Lactic acid
|
200-018-0 | 50-21-5 | Active | Full | Joint | ≥ 100 to < 1 000 tonnes | 04-01-2023 | View substance registered dossier |
|
Hydrocortisone
|
200-020-1 | 50-23-7 | Active | Intermediate | Joint | Intermediate use only | 06-12-2022 | View substance registered dossier |
|
Prednisolone
|
200-021-7 | 50-24-8 | Active | Full | Joint | ≥ 10 to < 100 tonnes | 04-05-2022 | View substance registered dossier |
|
Estradiol
|
200-023-8 | 50-28-2 | Active | Full | Joint | ≥ 1 to < 10 tonnes | 10-11-2021 | View substance registered dossier |
|
2,3-dichlorobenzoic acid
|
200-039-5 | 50-45-3 | Active | Intermediate | Joint | Intermediate use only | 17-04-2020 | View substance registered dossier |
|
Desipramine
|
200-040-0 | 50-47-5 | Active | Intermediate | Joint | Intermediate use only | 08-02-2018 | View substance registered dossier |
|
Amitriptyline
|
200-041-6 | 50-48-6 | Active | Intermediate | Joint | Intermediate use only | 11-10-2018 | View substance registered dossier |
|
Imipramine
|
200-042-1 | 50-49-7 | Active | Intermediate | Joint | Intermediate use only | 08-03-2018 | View substance registered dossier |
|
Thioridazine
|
200-044-2 | 50-52-2 | Active | Intermediate | Joint | Intermediate use only | 19-03-2018 | View substance registered dossier |
|
Chlorpromazine
|
200-045-8 | 50-53-3 | Active | Intermediate | Joint | Intermediate use only | 16-05-2017 | View substance registered dossier |
|
D-ribose
|
200-059-4 | 50-69-1 | Active | Full | Joint | ≥ 0 to < 10 tonnes | 03-05-2019 | View substance registered dossier |
|
D-ribose
|
200-059-4 | 50-69-1 | Active | Intermediate | Joint | Intermediate use only | 15-09-2020 | View substance registered dossier |
|
O-acetylsalicylic acid
|
200-064-1 | 50-78-2 | Active | Full | Joint | ≥ 100 to < 1 000 tonnes | 02-04-2013 | View substance registered dossier |
|
O-acetylsalicylic acid
|
200-064-1 | 50-78-2 | Active | Intermediate | Individual | Intermediate use only | 27-03-2015 | View substance registered dossier |
|
2-hydroxy-p-toluic acid
|
200-068-3 | 50-85-1 | No longer Valid | Full | Joint | No longer valid | 15-02-2018 | View substance registered dossier |
|
2-hydroxy-p-toluic acid
|
200-068-3 | 50-85-1 | Active | Intermediate | Joint | Intermediate use only | 22-09-2021 | View substance registered dossier |
|
Thymidine
|
200-070-4 | 50-89-5 | Active | Full | Joint | ≥ 1 000 to < 10 000 tonnes | 02-09-2014 | View substance registered dossier |
|
α-phenyl-1H-benzimidazole-2-methanol
|
200-073-0 | 50-97-5 | Active | Full | Joint | ≥ 1 to < 10 tonnes | 14-10-2022 | View substance registered dossier |
|
Ephedrine hydrochloride
|
200-074-6 | 50-98-6 | Active | Intermediate | Joint | Intermediate use only | 08-11-2018 | View substance registered dossier |
|
2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
|
200-076-7 | 51-03-6 | Active | Full | Joint | ≥ 1 000 to < 10 000 tonnes | 28-03-2022 | View substance registered dossier |
|
2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
|
200-076-7 | 51-03-6 | No longer Valid | Full | Individual | No longer valid | 02-07-2013 | View substance registered dossier |
|
Procaine hydrochloride
|
200-077-2 | 51-05-8 | Active | Intermediate | Joint | Intermediate use only | 02-07-2018 | View substance registered dossier |
|
Benzimidazole
|
200-081-4 | 51-17-2 | Active | Full | Joint | ≥ 10 to < 100 tonnes | 09-12-2021 | View substance registered dossier |
|
Fluorouracil
|
200-085-6 | 51-21-8 | Active | Intermediate | Joint | Intermediate use only | 29-05-2018 | View substance registered dossier |
|
2,4-dinitrophenol
|
200-087-7 | 51-28-5 | Active | Full | Joint | ≥ 100 to < 1 000 tonnes | 09-03-2022 | View substance registered dossier |
|
Hyoscine
|
200-090-3 | 51-34-3 | Active | Full | Joint | ≥ 10 to < 100 tonnes | 25-11-2021 | View substance registered dossier |
|
L-4-hydroxyproline
|
200-091-9 | 51-35-4 | Active | Full | Joint | ≥ 10 to < 100 tonnes | 27-04-2022 | View substance registered dossier |
|
L-4-hydroxyproline
|
200-091-9 | 51-35-4 | Active | Intermediate | Joint | Intermediate use only | 03-05-2018 | View substance registered dossier |
|
3,5-dichlorobenzoic acid
|
200-092-4 | 51-36-5 | Active | Intermediate | Joint | Intermediate use only | 20-09-2019 | View substance registered dossier |
|
DL-thyroxin
|
200-101-1 | 51-48-9 | Active | Full | Individual | ≥ 1 to < 10 tonnes | 10-09-2021 | View substance registered dossier |
|
Dexamphetamine
|
200-112-1 | 51-64-9 | Active | Intermediate | Joint | Intermediate use only | 23-10-2018 | View substance registered dossier |
|
4-(2-aminoethyl)phenol
|
200-115-8 | 51-67-2 | Active | Intermediate | Joint | Intermediate use only | 05-01-2016 | View substance registered dossier |
|
4-(2-aminoethyl)phenol
|
200-115-8 | 51-67-2 | Cease Manufacture | Full | Joint | Cease manufacture | 06-03-2018 | View substance registered dossier |
|
N,N,N',N'-tetramethylmethylenediamine
|
200-124-7 | 51-80-9 | Active | Intermediate | Joint | Intermediate use only | 29-10-2014 | View substance registered dossier |
|
Morphine hydrochloride
|
200-136-2 | 52-26-6 | Active | Intermediate | Joint | Intermediate use only | 16-03-2017 | View substance registered dossier |
|
Bronopol
|
200-143-0 | 52-51-7 | Active | Full | Joint | ≥ 100 to < 1 000 tonnes | 01-12-2022 | View substance registered dossier |
|
Cysteine hydrochloride
|
200-157-7 | 52-89-1 | Active | Full | Joint | ≥ 1 000 to < 10 000 tonnes | 07-12-2022 | View substance registered dossier |
|
L-cysteine
|
200-158-2 | 52-90-4 | Active | Full | Joint | ≥ 10 to < 100 tonnes | 10-11-2020 | View substance registered dossier |
|
L-cysteine
|
200-158-2 | 52-90-4 | Active | Intermediate | Joint | Intermediate use only | 30-01-2019 | View substance registered dossier |
|
Estrone
|
200-164-5 | 53-16-7 | Active | Full | Joint | ≥ 10 to < 100 tonnes | 24-08-2021 | View substance registered dossier |
|
Methylprednisolone 21-acetate
|
200-171-3 | 53-36-1 | Active | Intermediate | Joint | Intermediate use only | 14-01-2022 | View substance registered dossier |
|
Prasterone
|
200-175-5 | 53-43-0 | Active | Intermediate | Joint | Intermediate use only | 26-08-2022 | View substance registered dossier |
|
Nadide
|
200-184-4 | 53-84-9 | Active | Full | Joint | ≥ 1 to < 10 tonnes | 11-03-2022 | View substance registered dossier |
|
Indometacin
|
200-186-5 | 53-86-1 | Active | Intermediate | Joint | Intermediate use only | 28-03-2018 | View substance registered dossier |
|
Nicotine
|
200-193-3 | 54-11-5 | Active | Full | Joint | ≥ 1 000 to < 10 000 tonnes | 04-04-2022 | View substance registered dossier |
|
Nicotine
|
200-193-3 | 54-11-5 | Active | Intermediate | Individual | Intermediate use only | 14-04-2021 | View substance registered dossier |
|
Sodium salicylate
|
200-198-0 | 54-21-7 | Active | Full | Joint | ≥ 100 to < 1 000 tonnes | 17-06-2020 | View substance registered dossier |
| Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
|---|---|---|---|---|---|---|---|---|
| [Confidential] | - | - | - | Hydrocortisone 21-acetate | 200-004-4 | 50-03-3 | - | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Cease Manufacture | Hydrocortisone 21-acetate | 200-004-4 | 50-03-3 | 2012 | View substance registered dossier |
| EUROAPI FRANCE | 15 rue Traversière 75012 Paris France | France | Active | Cortisone 21-acetate | 200-006-5 | 50-04-4 | 2021; 2022 | View substance registered dossier |
| Alkaloida Chemical Company Zrt. | Kabay Janos 29 H-4440 Tiszavasvari Hungary | Hungary | Active | Phenobarbital | 200-007-0 | 50-06-6 | - | View substance registered dossier |
| SIGMA-ALDRICH CHEMIE GMBH | Riedstrasse 2 89555 Steinheim Germany | Germany | Active | Lactic acid | 200-018-0 | 50-21-5 | 2021 | View substance registered dossier |
| Sacco S.r.l. | via Alessandro Manzoni 29a 22071 Cadorago Como Italy | Italy | Active | Lactic acid | 200-018-0 | 50-21-5 | - | View substance registered dossier |
| Chementors Oy | Smart Chemistry Park Raisionkaari 55 21200 Raisio Finland | Finland | Active | Lactic acid | 200-018-0 | 50-21-5 | 2021 | View substance registered dossier |
| Purac Biochem bv | Arkelsedijk 46 4206AC Gorinchem Netherlands | Netherlands | Active | Lactic acid | 200-018-0 | 50-21-5 | 2018; 2021; 2022 | View substance registered dossier |
| Galactic | Place d'Escanaffles 23 7760 Escanaffles Belgium | Belgium | Active | Lactic acid | 200-018-0 | 50-21-5 | 2022 | View substance registered dossier |
| BIOFER SpA | Via Tommaso da Cazzaniga 9/6 20121 Milano Milano Italy | Italy | Active | Hydrocortisone | 200-020-1 | 50-23-7 | 2012; 2013; 2021 | View substance registered dossier |
| NEWCHEM S.P.A. | VIA EDMONDO DE AMICIS 47 20123 MILANO ITALY Italy | Italy | Active | Hydrocortisone | 200-020-1 | 50-23-7 | 2013 | View substance registered dossier |
| RSI ChemRep Europe Ltd (P001) | 27-30 Merchants Quay Merchants House 8 Dublin Ireland | Ireland | Active | Hydrocortisone | 200-020-1 | 50-23-7 | 2021; 2022 | View substance registered dossier |
| [Confidential] | - | - | - | Hydrocortisone | 200-020-1 | 50-23-7 | - | View substance registered dossier |
| VALDEPHARM | Parc Industriel d'Incarville CS10606 27106 Val de Reuil France | France | Active | Hydrocortisone | 200-020-1 | 50-23-7 | 2012 | View substance registered dossier |
| Farmabios Spa | Via Pavia, 1 27027 Gropello Cairoli PV Italy | Italy | Active | Hydrocortisone | 200-020-1 | 50-23-7 | - | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Cease Manufacture | Hydrocortisone | 200-020-1 | 50-23-7 | 2015 | View substance registered dossier |
| ZaCh System | ZI La Croix Cadeaux 49242 Avrillè France | France | Active | Prednisolone | 200-021-7 | 50-24-8 | - | View substance registered dossier |
| CURIA SPAIN, S.A.U. | Parque Tecnológico de Boecillo, parcela 105 47151 Boecillo Valladolid Spain | Spain | Active | Prednisolone | 200-021-7 | 50-24-8 | - | View substance registered dossier |
| Farmabios Spa | Via Pavia, 1 27027 Gropello Cairoli PV Italy | Italy | Active | Prednisolone | 200-021-7 | 50-24-8 | 2011 | View substance registered dossier |
| [Confidential] | - | - | - | Prednisolone | 200-021-7 | 50-24-8 | - | View substance registered dossier |
| Steroid SpA | Viale Spagna 156 20093 Cologno Monzese Milano Italy | Italy | Active | Prednisolone | 200-021-7 | 50-24-8 | - | View substance registered dossier |
| Aspen Oss BV | Kloosterstraat 6 5349 AB Oss Netherlands | Netherlands | Cease Manufacture | Prednisolone | 200-021-7 | 50-24-8 | 2022 | View substance registered dossier |
| NEWCHEM S.P.A. | VIA EDMONDO DE AMICIS 47 20123 MILANO ITALY Italy | Italy | Active | Prednisolone | 200-021-7 | 50-24-8 | 2013 | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Active | Estradiol | 200-023-8 | 50-28-2 | 2012; 2017; 2021 | View substance registered dossier |
| VALDEPHARM | Parc Industriel d'Incarville CS10606 27106 Val de Reuil France | France | Active | Estradiol | 200-023-8 | 50-28-2 | 2012; 2018 | View substance registered dossier |
| Gedeon Richter Plc. | Gyomroi ut 19-21 1103 Budapest Hungary | Hungary | Active | 2,3-dichlorobenzoic acid | 200-039-5 | 50-45-3 | 2020 | View substance registered dossier |
| Lundbeck Pharmaceuticals Italy S.p.A | via quarta strada 2 35129 padova Italy | Italy | Active | Desipramine | 200-040-0 | 50-47-5 | - | View substance registered dossier |
| OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Cease Manufacture | Amitriptyline | 200-041-6 | 50-48-6 | 2022 | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden | Sweden | Active | Amitriptyline | 200-041-6 | 50-48-6 | - | View substance registered dossier |
| Sigma-Aldrich Ireland Ltd | Vale Road . Arklow Co. Wicklow Ireland | Ireland | Active | Amitriptyline | 200-041-6 | 50-48-6 | - | View substance registered dossier |
| Lundbeck Pharmaceuticals Italy S.p.A | via quarta strada 2 35129 padova Italy | Italy | Active | Imipramine | 200-042-1 | 50-49-7 | - | View substance registered dossier |
| Corden Pharma Bergamo S.p.A. | Via Bergamo, 121 IT-24047 Treviglio BG Italy | Italy | Active | Imipramine | 200-042-1 | 50-49-7 | - | View substance registered dossier |
| PCAS Finland Oy | Messukentänkatu 8 20210 TURKU Finland | Finland | Active | Imipramine | 200-042-1 | 50-49-7 | - | View substance registered dossier |
| Trifarma S.p.A. | Via G. Guarini Matteucci 1 20162 Milan (MI) Italy | Italy | Active | Thioridazine | 200-044-2 | 50-52-2 | - | View substance registered dossier |
| sanofi chimie | 82 avenue Raspail 94250 Gentilly France | France | Active | Chlorpromazine | 200-045-8 | 50-53-3 | - | View substance registered dossier |
| LUCAS MEYER COSMETICS | 13 rue Ella Maillart Campus Eiffel - Bâtiment Edison 91300 MASSY Ile-De-France France | France | Active | D-ribose | 200-059-4 | 50-69-1 | 2019 | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | D-ribose | 200-059-4 | 50-69-1 | - | View substance registered dossier |
| SONEAS Chemicals Ltd. | Banyaleg Str. 47-59. H-1225 Budapest Hungary | Hungary | Active | D-ribose | 200-059-4 | 50-69-1 | - | View substance registered dossier |
| Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | D-ribose | 200-059-4 | 50-69-1 | - | View substance registered dossier |
| Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Active | D-ribose | 200-059-4 | 50-69-1 | - | View substance registered dossier |
| QUIMDIS SAS | 71, rue Anatole France 92532 Levallois-Perret France | France | Active | D-ribose | 200-059-4 | 50-69-1 | - | View substance registered dossier |
| NOVACYL SAS | 21 chemin de la Sauvegarde « 21 Ecully Parc » - CS 33167 69134 ECULLY CEDEX France | France | Active | O-acetylsalicylic acid | 200-064-1 | 50-78-2 | - | View substance registered dossier |
| Sanofi Winthrop Industrie | 20, avenue Raymond Aron 92165 Antony Cedex France | France | Active | O-acetylsalicylic acid | 200-064-1 | 50-78-2 | 2015 | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | Sweden | No longer Valid | 2-hydroxy-p-toluic acid | 200-068-3 | 50-85-1 | 2021 | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden | Sweden | Active | 2-hydroxy-p-toluic acid | 200-068-3 | 50-85-1 | - | View substance registered dossier |
| Zach System | ZI La Croix Cadeau 49242 Avrillé France | France | Active | 2-hydroxy-p-toluic acid | 200-068-3 | 50-85-1 | 2021 | View substance registered dossier |
| [Confidential] | - | - | - | Thymidine | 200-070-4 | 50-89-5 | - | View substance registered dossier |
| Nalco Europe B.V. | Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands | Netherlands | Active | α-phenyl-1H-benzimidazole-2-methanol | 200-073-0 | 50-97-5 | 2022 | View substance registered dossier |
| Aceto France SAS | 3 Rue de Genève CS 50363 BP 50367 Lyon Cedex 06 France | France | Active | Ephedrine hydrochloride | 200-074-6 | 50-98-6 | - | View substance registered dossier |
| Siegfried PharmaChemikalien Minden GmbH | Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany | Germany | Active | Ephedrine hydrochloride | 200-074-6 | 50-98-6 | 2018 | View substance registered dossier |
| ENDURA S.p.A. | Viale Pietramellara, 5 40121 Bologna Italy | Italy | Active | 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether | 200-076-7 | 51-03-6 | 2014; 2020; 2022 | View substance registered dossier |
| Copyr S.p.A. | Via G. Stephenson 73 20157 Milano Italy | Italy | No longer Valid | 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether | 200-076-7 | 51-03-6 | 2017 | View substance registered dossier |
| ADL Biopharma S.L.U | Avda. Antibióticos, 59 - 61 24009 León Spain | Spain | Active | Procaine hydrochloride | 200-077-2 | 51-05-8 | - | View substance registered dossier |
| OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | Procaine hydrochloride | 200-077-2 | 51-05-8 | 2017; 2018 | View substance registered dossier |
| REACH24H CONSULTING GROUP | Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland | Ireland | Active | Procaine hydrochloride | 200-077-2 | 51-05-8 | - | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | Sweden | Active | Benzimidazole | 200-081-4 | 51-17-2 | 2017; 2018 | View substance registered dossier |
| REACHLINKED OÜ | Ahtri tn 12 10151 Tallinn Estonia | Estonia | Active | Benzimidazole | 200-081-4 | 51-17-2 | 2019 | View substance registered dossier |
| [Confidential] | - | - | - | Benzimidazole | 200-081-4 | 51-17-2 | - | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | Fluorouracil | 200-085-6 | 51-21-8 | - | View substance registered dossier |
| JSC Grindeks | 53 Krustpils St LV 1057 Riga Latvia | Latvia | Cease Manufacture | Fluorouracil | 200-085-6 | 51-21-8 | 2022 | View substance registered dossier |
| Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Active | Fluorouracil | 200-085-6 | 51-21-8 | 2012 | View substance registered dossier |
| REACH&Colours Kft | Petofi Sandor utca 11 I Em. 4 1052 Budapest Hungary | Hungary | Active | 2,4-dinitrophenol | 200-087-7 | 51-28-5 | 2021 | View substance registered dossier |
| DyStar Colours Distribution GmbH | Am Prime-Parc 12 65479 Raunheim Germany | Germany | Active | 2,4-dinitrophenol | 200-087-7 | 51-28-5 | 2022 | View substance registered dossier |
| Reach & Colours Trade Kft | Levente u. 14/a 2161 Csomád Hungary | Hungary | Active | 2,4-dinitrophenol | 200-087-7 | 51-28-5 | 2021 | View substance registered dossier |
| Boehringer Ingelheim Pharma GmbH & Co. KG | Binger Strasse 173 55216 Ingelheim am Rhein Germany | Germany | Active | Hyoscine | 200-090-3 | 51-34-3 | 2017; 2021 | View substance registered dossier |
| Evonik Rexim S.A.S. | 33, Rue de Verdun 80400 Ham France | France | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | - | View substance registered dossier |
| FERRANIA CHEMICALS S.R.L. | Viale della Libertà, 57 17014 Cairo Montenotte (SV) Italy | Italy | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | - | View substance registered dossier |
| Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | - | View substance registered dossier |
| Life Technologies Europe BV | Kwartsweg 2 2665 NN Bleiswijk Netherlands | Netherlands | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | - | View substance registered dossier |
| Global Life Sciences Solutions Austria GmbH & Co KG | Kremplstraße 5 4061 Pasching Austria | Austria | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | - | View substance registered dossier |
| Kyowa Hakko Bio Italia S.r.l. | Viale Piero e Alberto Pirelli, 6 20126 Milano Italy | Italy | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | - | View substance registered dossier |
| Kyowa Hakko Europe GmbH | Am Wehrhahn 50 40211 Düsseldorf Germany | Germany | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | 2022 | View substance registered dossier |
| CHEMSAFE srl on behalf of AZO INTERNATIONAL CHEMICAL ltd | Via Ribes, 5 10010 Colleretto Giacosa TO Italy | Italy | Active | L-4-hydroxyproline | 200-091-9 | 51-35-4 | - | View substance registered dossier |
| Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | 3,5-dichlorobenzoic acid | 200-092-4 | 51-36-5 | - | View substance registered dossier |
| Sandoz GmbH | Biochemiestr. 10 6250 Kundl Austria | Austria | Active | DL-thyroxin | 200-101-1 | 51-48-9 | 2021 | View substance registered dossier |
| SYNTHEXIM | 1 Quai d'Amérique 62 100 calais France | France | Active | Dexamphetamine | 200-112-1 | 51-64-9 | - | View substance registered dossier |
| OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | 4-(2-aminoethyl)phenol | 200-115-8 | 51-67-2 | - | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | Sweden | Cease Manufacture | 4-(2-aminoethyl)phenol | 200-115-8 | 51-67-2 | 2022 | View substance registered dossier |
| Taminco BV | Pantserschipstraat 207 9000 Gent Belgium | Belgium | Active | N,N,N',N'-tetramethylmethylenediamine | 200-124-7 | 51-80-9 | - | View substance registered dossier |
| [Confidential] | - | - | - | Morphine hydrochloride | 200-136-2 | 52-26-6 | - | View substance registered dossier |
| CHEMICAL INSPECTION & REGULATION SERVICE LIMITED | Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland | Ireland | Active | Bronopol | 200-143-0 | 52-51-7 | - | View substance registered dossier |
| Lanxess Deutschland GmbH | Kennedyplatz 1 50569 Köln Germany | Germany | Active | Bronopol | 200-143-0 | 52-51-7 | - | View substance registered dossier |
| BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Active | Bronopol | 200-143-0 | 52-51-7 | 2019; 2022 | View substance registered dossier |
| MC (Netherlands) 1 B.V. | Willem Einthovenstraat 4 2342BH Oegstgeest Netherlands | Netherlands | Active | Bronopol | 200-143-0 | 52-51-7 | - | View substance registered dossier |
| THOR GmbH | Landwehrstrasse 1 D-67346 Speyer Rheinland-Pfalz Germany | Germany | Active | Bronopol | 200-143-0 | 52-51-7 | - | View substance registered dossier |
| THOR ESPECIALIDADES, S.A. | AVDA. DE LA INDUSTRIA, 1 - POL. IND. EL PLA 08297 CASTELLGALI BARCELONA Spain | Spain | Active | Bronopol | 200-143-0 | 52-51-7 | - | View substance registered dossier |
| NetSun EU B.V. | Blaak 40, Fifth Floor 3011 TA Rotterdam Netherlands | Netherlands | Cease Manufacture | Cysteine hydrochloride | 200-157-7 | 52-89-1 | 2019 | View substance registered dossier |
| Sigma-Aldrich Ireland Ltd | Vale Road . Arklow Co. Wicklow Ireland | Ireland | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| Wacker Chemie AG | Hanns-Seidel-Platz 4 81737 Muenchen Germany | Germany | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | 2016; 2017; 2018 | View substance registered dossier |
| Sanofi Aventis Deutschland GmbH | Industriepark Höchst H 831 (Room A0472) z.Hd. Hr. Dr. Schwind 65926 Frankfurt am Main Germany | Germany | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| PharmaZell GmbH | Rosenheimer Straße 43 D-83064 Raubling Germany | Germany | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| Sigma-Aldrich Company Limited | The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom | United Kingdom | No longer Valid | Cysteine hydrochloride | 200-157-7 | 52-89-1 | 2021 | View substance registered dossier |
| Merck KGaA | Frankfurter Strasse 250 64293 Darmstadt Germany | Germany | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| SAFC Biosciences Limited | Smeaton Road, West Potway SP10 3LF Andover United Kingdom | United Kingdom | No longer Valid | Cysteine hydrochloride | 200-157-7 | 52-89-1 | 2021 | View substance registered dossier |
| B-Lands Consulting (811703-4) | OR of Wuhan Grand hoyo Co, . Ltd 5 Place Robert Schuman - BP 1516 38025 Grenoble France France | France | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| Global Life Sciences Solutions Austria GmbH & Co KG | Kremplstraße 5 4061 Pasching Austria | Austria | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| CJ Europe GmbH | Unterschweinstiege 2-14 60549 Frankfurt am Main Germany | Germany | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| SIGMA-ALDRICH CHEMIE GMBH | Riedstrasse 2 89555 Steinheim Germany | Germany | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| B-Lands Consulting (811700-5) | OR of Shine Star (Hubei) Biological Engineering Co., Ltd 5 Place Robert Schuman - BP 1516 38025 Grenoble France France | France | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | 2021 | View substance registered dossier |
| Life Technologies Europe BV | Kwartsweg 2 2665 NN Bleiswijk Netherlands | Netherlands | Active | Cysteine hydrochloride | 200-157-7 | 52-89-1 | - | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | L-cysteine | 200-158-2 | 52-90-4 | - | View substance registered dossier |
| Sigma-Aldrich Ireland Ltd | Vale Road . Arklow Co. Wicklow Ireland | Ireland | Active | L-cysteine | 200-158-2 | 52-90-4 | - | View substance registered dossier |
| Sterling Pharma Solutions Ltd | Dudley NE23 7QG Cramlington Northumberland United Kingdom | United Kingdom | No longer Valid | L-cysteine | 200-158-2 | 52-90-4 | 2021 | View substance registered dossier |
| B-Lands Consulting (811703-4) | OR of Wuhan Grand hoyo Co, . Ltd 5 Place Robert Schuman - BP 1516 38025 Grenoble France France | France | Active | L-cysteine | 200-158-2 | 52-90-4 | - | View substance registered dossier |
| Sigma-Aldrich Company Limited | The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom | United Kingdom | No longer Valid | L-cysteine | 200-158-2 | 52-90-4 | 2021 | View substance registered dossier |
| Wacker Chemie AG | Hanns-Seidel-Platz 4 81737 Muenchen Germany | Germany | Active | L-cysteine | 200-158-2 | 52-90-4 | 2016 | View substance registered dossier |
| SIGMA-ALDRICH CHEMIE GMBH | Riedstrasse 2 89555 Steinheim Germany | Germany | Active | L-cysteine | 200-158-2 | 52-90-4 | - | View substance registered dossier |
| PROCOS SpA | via Matteotti 249 28062 Cameri Piemonte Italy | Italy | Active | L-cysteine | 200-158-2 | 52-90-4 | - | View substance registered dossier |
| Aceto France SAS | 3 Rue de Genève CS 50363 BP 50367 Lyon Cedex 06 France | France | Active | L-cysteine | 200-158-2 | 52-90-4 | - | View substance registered dossier |
| Aspen Oss BV | Kloosterstraat 6 5349 AB Oss Netherlands | Netherlands | Active | Estrone | 200-164-5 | 53-16-7 | 2011; 2012; 2017 | View substance registered dossier |
| Aceto France SAS | 3 Rue de Genève CS 50363 BP 50367 Lyon Cedex 06 France | France | Active | Estrone | 200-164-5 | 53-16-7 | - | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Active | Estrone | 200-164-5 | 53-16-7 | 2011; 2017 | View substance registered dossier |
| REACH24H CONSULTING GROUP | Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland | Ireland | Active | Estrone | 200-164-5 | 53-16-7 | - | View substance registered dossier |
| DKSH France S.A. | 1475 Quai du Rhone 01702 Miribel France | France | Active | Estrone | 200-164-5 | 53-16-7 | 2011 | View substance registered dossier |
| [Confidential] | - | - | - | Estrone | 200-164-5 | 53-16-7 | - | View substance registered dossier |
| EUROAPI FRANCE | 15 rue Traversière 75012 Paris France | France | Active | Methylprednisolone 21-acetate | 200-171-3 | 53-36-1 | 2021; 2022 | View substance registered dossier |
| REACH24H CONSULTING GROUP | Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland | Ireland | Active | Prasterone | 200-175-5 | 53-43-0 | - | View substance registered dossier |
| Gedeon Richter Plc. | Gyomroi ut 19-21 1103 Budapest Hungary | Hungary | Active | Prasterone | 200-175-5 | 53-43-0 | - | View substance registered dossier |
| Sicor - Società Italiana Corticosteroidi S.r.l. | Piazzale Luigi Cadorna 4 20123 Milano (MI) Italy | Italy | Active | Prasterone | 200-175-5 | 53-43-0 | - | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | No longer Valid | Prasterone | 200-175-5 | 53-43-0 | - | View substance registered dossier |
| Industriale Chimica s.r.l. | via E.H. Grieg, 13 21074 Saronno (VA) Italy | Italy | Active | Prasterone | 200-175-5 | 53-43-0 | 2019 | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Active | Prasterone | 200-175-5 | 53-43-0 | 2022 | View substance registered dossier |
| OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Cease Manufacture | Prasterone | 200-175-5 | 53-43-0 | 2022 | View substance registered dossier |
| Roche Diagnostics GmbH | Sandhoferstrasse 116 68305 Mannheim Germany | Germany | Active | Nadide | 200-184-4 | 53-84-9 | 2019; 2022 | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Cease Manufacture | Indometacin | 200-186-5 | 53-86-1 | 2021 | View substance registered dossier |
| Cosma S.p.A. | Via Colleoni 15/17 24040 Ciserano (BG) Italy | Italy | Active | Indometacin | 200-186-5 | 53-86-1 | - | View substance registered dossier |
| Global Product Compliance (Europe) AB (acting as OR for BGP Healthcare Pvt. Ltd., India) | IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden | Sweden | Active | Nicotine | 200-193-3 | 54-11-5 | 2019 | View substance registered dossier |
| REACHLaw Ltd(acting as OR for QUAD LIFESCIENCES PRIVATE LIMITED) | Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland | Finland | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| CHEMNOVATIC Sp. z o.o. Sp. k. | Ludwika Spiessa 9 20-270 Lublin lubelskie Poland | Poland | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| REACHLaw Ltd. | Vänrikinkuja 3 JK 21, FI-02600 Espoo Finland | Finland | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| Contraf-Nicotex-Tobacco GmbH | Herbststr. 8 74072 Heilbronn Germany | Germany | Active | Nicotine | 200-193-3 | 54-11-5 | 2015; 2018; 2019 | View substance registered dossier |
| Chemservice GmbH - (A2C5) | Herrnsheimer Hauptstrasse 1b 67550 Worms Germany | Germany | Active | Nicotine | 200-193-3 | 54-11-5 | 2018; 2022 | View substance registered dossier |
| Nicobrand Limited | 189 Castleroe Road BT51 3RP Coleraine Londonderry United Kingdom (Northern Ireland) | United Kingdom (Northern Ireland) | Active | Nicotine | 200-193-3 | 54-11-5 | 2018 | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | Sweden | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| HiLIQ Bartosz Blak | Drewnowskiego 5/4 05-131 Zegrze Poland | Poland | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| A-sense Sp. z o.o. | Mościckiego 1 24-100 Puławy Poland | Poland | Active | Nicotine | 200-193-3 | 54-11-5 | 2022 | View substance registered dossier |
| GAIATREND | 10, route de Strasbourg 57410 ROHRBACH LES BITCHE France | France | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| CHEMNOVATIC R&D Sp. z o.o. | Ludwika Spiessa 9 20-270 Lublin Poland | Poland | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| Siegfried PharmaChemikalien Minden GmbH | Karlstr. 15-39, 42-44 32423 Minden Nordrhein-Westphalen Germany | Germany | Active | Nicotine | 200-193-3 | 54-11-5 | - | View substance registered dossier |
| Red Orchid Consulting Oy Ltd (YIXING CITY SHENGUANG MEDICINE CHEMICALS CO., LTD.) | Viherkallionkuja 3 I 59 02710 Espoo, Finland. 02710 Espoo Finland | Finland | Active | Sodium salicylate | 200-198-0 | 54-21-7 | 2014; 2018 | View substance registered dossier |
| NOVEAL | 16 rue Maurice Berteaux 95500 LE THILLAY France | France | Active | Sodium salicylate | 200-198-0 | 54-21-7 | 2019 | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden | Sweden | Active | Sodium salicylate | 200-198-0 | 54-21-7 | 2013; 2014; 2018; 2019 | View substance registered dossier |
| Chemreach GmbH | Akazienweg 30 48317 Drensteinfurt Germany | Germany | Active | Sodium salicylate | 200-198-0 | 54-21-7 | - | View substance registered dossier |
| Merck KGaA | Frankfurter Strasse 250 64293 Darmstadt Germany | Germany | Active | Sodium salicylate | 200-198-0 | 54-21-7 | - | View substance registered dossier |
| PHARMEGIC HEALTHCARE LIMITED | Konstitucijos av. 21A, 08130 Vilnius Lithuania Ireland | Ireland | Active | Sodium salicylate | 200-198-0 | 54-21-7 | - | View substance registered dossier |
| Biesterfeld Spezialchemie GmbH | Ferdinandstr. 41 20095 Hamburg Germany | Germany | Active | Sodium salicylate | 200-198-0 | 54-21-7 | 2018; 2020 | View substance registered dossier |
| SIGMA-ALDRICH CHEMIE GMBH | Riedstrasse 2 89555 Steinheim Germany | Germany | Active | Sodium salicylate | 200-198-0 | 54-21-7 | - | View substance registered dossier |
| Brenntag Nederland B.V. | Donker Duyvisweg 44 3316 BM Dordrecht Netherlands | Netherlands | Active | Sodium salicylate | 200-198-0 | 54-21-7 | 2019 | View substance registered dossier |
| Global Product Compliance (Europe) AB | IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden | Sweden | Active | Sodium salicylate | 200-198-0 | 54-21-7 | - | View substance registered dossier |
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.